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. Author manuscript; available in PMC: 2013 Nov 19.
Published in final edited form as: Chem Res Toxicol. 2012 Aug 29;25(11):2423–2431. doi: 10.1021/tx300290b

Figure 2.

Figure 2

Contour plots of an expanded region of an 800 MHz NOESY spectrum (300 ms mixing time) recorded at 25 °C in 100% D2O buffer. The figure shows intra residue and sequential base (purine H8/pyrimidine H6) to sugar H1′ proton interactions for the modified (top) and unmodified (bottom) strands on the central (T3 T9)•(A14 A20) segment of the cFapy-dG•dC duplex. Red and blue colors trace these connectivities on the Z and E isomeric duplexes, respectively. Numbered letters label the intra residue NOE peaks and asterisks indicate cytosine(H5 H6) peaks. X identifies the F6(HCO) C5(H1′) NOE of the Z isomer.