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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Pharmacol Res. 2012 Sep 10;66(6):544–554. doi: 10.1016/j.phrs.2012.08.004

Figure 2.

Figure 2

(a–c) Representative tracings of rat aorta contraction, in response to rapid exposure to low-Na+ (~15 mM) physiological salt solution. Shown are responses from tissues incubated with vehicle (DMSO) (a), 1 μM KB-R7943 (b) and 10 μM KB-R7943 (c). Arrows indicate the baseline and maximal contraction used to measure the responses. (d,e) Summary graphs of low-Na+-induced contraction in aorta, in the presence or absence of KB-R7943 (1 μM and 10 μM). All bars represent mean ± SEM for the number of animals indicated. Black bars represent vehicle-exposed tissues (differences between vehicle contractions were not significant). White bars represent tissues exposed to 1 μM KB-R7943 (d) or 10 μM KB-R7943 (e). Results are shown as percentages of initial phenylephrine contraction (PE). N=3–5; * = p<0.05 versus vehicle.