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The effects of KB-R7943 (10 μM) on endothelin-1-induced contraction in aorta (a) and vena cava (b) exposed to L-NNA (100 μM) and indomethacin (5 μM). Vehicle or antagonists were incubated with tissue for 1h prior to ET-1 exposure. Points represent mean ± SEM for the number of animals indicated in parentheses. * = p<0.05 versus vehicle.
