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. Author manuscript; available in PMC: 2014 Feb 25.
Published in final edited form as: Mol Cell Endocrinol. 2012 Jun 28;366(2):163–169. doi: 10.1016/j.mce.2012.06.017

Figure 1. Core circadian clock machinery.

Figure 1

Mammalian circadian clocks are based on a transcription and translation feedback loop in which the transcription factors CLOCK and its heterodimeric partner BMAL1 activate the transcription of genes encoding their own inhibitors, the period (PER1, PER2 and PER3) and cryptochrome (CRY1 and CRY2) repressor proteins.