Figure 1.

Clinical and pathological findings of a patient with Castleman disease before tocilizumab treatment. Panel (a) shows the thoracic X-ray photograph before tocilizumab treatment. Bilateral hilar lymphadenopathy and infiltrative shadows can be seen in both lungs. The infiltrative shadows remained unchanged for several years. Panel (b) shows the histopathological findings of the pulmonary lymph node performed in the Chiba Cancer Center (×200). Infiltrations of polyclonal plasma cells surrounding the mantle zones and a pattern of concentric deposits with lymphoid cells can be seen. Combined with the typical clinical findings, the patient was diagnosed with Castleman disease. Panel (c) shows a slit-lamp photograph of the anterior chamber before tocilizumab treatment. Large cells (3+) without flare can be seen in the anterior chamber. Panel (d) shows FA findings detecting increased vascular permeability from the retinal vessels and hyper fluorescence of the optic discs in both eyes before treatment.