Table 2.
Assessment of associations between individual clinicopathologic tumor variables and time to PTC recurrence (events = 55).
| Variable | Hazard ratio | Confidence interval | p-value |
|---|---|---|---|
| Male | 2.08 | 1.21–3.59 | 0.01 |
| Age at surgery (per 10 yrs) | 1.02 | 0.85–1.23 | 0.83 |
| AJCC TNM - Tumor stage | |||
| T1 (< 2cm (reference)) | |||
| T2 (2–4 cm) | 1.06 | 0.50–2.24 | 0.88 |
| T3 (≥ 4 cm or minimal extrathyroidal extension) | 2.34 | 1.30–4.23 | 0.005 |
| T4 (gross ETE) | 4.30 | 0.58–31.9 | 0.15 |
| Tumor histological subtype | |||
| Normal risk (reference) | |||
| Low risk* | 0.00 | - | - |
| High risk | 1.20 | 0.29–4.94 | 0.80 |
| Central neck LN positivity | 1.87 | 1.10–3.19 | 0.02 |
| Lateral neck LN positivity | 2.69 | 1.48–4.86 | 0.001 |
| Lymphovascular invasion | 2.89 | 1.45–5.73 | 0.002 |
| Tumor multifocality | 2.11 | 1.21–3.67 | 0.01 |
| BRAFV600E+ | 2.62 | 1.17–5.88 | 0.02 |
*
No patients with low risk histological subtypes recurred leading to model non-convergence.