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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Biochem Soc Trans. 2012 Oct;40(5):969–974. doi: 10.1042/BST20120094

Figure 2. PP1 regulators are IDPs that adopt distinct conformations in their PP1-bound forms.

Figure 2

(A) PP1 is a metalloenzyme with two Mn2 + ions bound at the catalytic site. The catalytic site is also the target of molecular toxins such as Nodularin-R. (B) Gm peptide–PP1 complex; electron density for the peptide was only detected in the RVXF-binding site. (C) Spinophilin–PP1 complex (PDB code 3EGG). (D) I-2–PP1 complex (PDB code 2O8G). (E) MYPT1–PP1 complex (PDB code 1S70).