Table I.
Selected Up or DownRegulated Genes in SBNETs and PNETs Relative to Normal Tissue by Exon Arrays
| SBNET vs. Normal | PNET vs. Normal | ||||
|---|---|---|---|---|---|
| Gene | Gene Name | Fold-Change | p-value | Fold-change | p-value |
| TTR | Transthyretin | +28.61 | 2.20E-06 | +1.51 | 5.70E-03 |
| SLC18A1 | Solute Carrier Family 18 (Vesicular Monoamine), Member 1 | +22.06 | 3.40E-06 | −1.30 | 1.68E-01 |
| TAC1 | Tachykinin, Precursor 1 | +18.74 | 1.26E-06 | −1.35 | 6.28E-02 |
| TPH1 | Tryptophan Hydroxylase 1 | +17.71 | 7.82E-05 | +2.04 | 1.13E-01 |
| CHGB | Chromogranin B (Secretogranin 1) | +17.45 | 4.71E-05 | +7.38 | 8.00E-04 |
| OR51E1* | Olfactory Receptor, Family 51, Subfamily E, Member 1 | +5.27 | 9.84E-04 | −1.21 | 1.86E-02 |
| GPR112* | G-Protein Coupled Receptor 112 | +5.05 | 1.10E-03 | −1.13 | 3.20E-03 |
| DEFA6 | Defensin, Alpha 6, Paneth Cell-Specific | −28.16 | 1.98E-06 | +1.05 | 4.94E-01 |
| SI | Sucrase-Isomaltase (Alpha-Glucosidase) | −24.31 | 1.21E-05 | +1.89 | 2.95E-01 |
| MEP1B | Meprin A, Beta | −23.71 | 4.97E-07 | +10.04 | 1.63E-02 |
| FGB | Fibrinogen Beta Chain | +1.17 | 3.02E-01 | +26.63 | 4.93E-06 |
| IL13RA2 | Interleukin 13 Receptor, Alpha 2 | +1.10 | 4.65E-01 | +18.15 | 4.79E-04 |
| MUC13 | Mucin 13, Cell Surface Associated | −4.65 | 8.00E-04 | +13.61 | 4.79E-04 |
| POSTN | Periostin, Osteoblast Specific Factor | +1.23 | 6.08E-01 | +13.17 | 1.38E-02 |
| KBTBD10 | Kelch Repeat and BTB (POZ) Domain Containing 10 | +1.18 | 1.65E-01 | +12.86 | 1.30E-04 |
| ANPEP | Alanyl (Membrane) Aminopeptidase | −13.07 | 7.75E-06 | −10.57 | 1.54E-02 |
| PDIA2 | Protein Disulfide Isomerase Family A, Member 2 | −1.19 | 8.65E-02 | −9.61 | 1.98E-02 |
| LGALS2 | Lectin, Galactoside-Binding, Soluble, 2 | −4.68 | 9.79E-05 | −8.01 | 2.36E-02 |
| F11 | Coagulation Factor XI | −1.62 | 9.50E-03 | −7.56 | 1.37E-02 |
| TRHDE | Thyrotropin-Releasing Hormone Degrading Enzyme | −2.13 | 3.85E-04 | −7.36 | 1.19E-02 |
*
members of GPCR gene family; Gray coloration indicates the primary site of interest with its significantly up and downregulated genes using the Exon Arrays. Non-shaded areas are from the alternate site for comparison