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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Surgery. 2012 Dec;152(6):998–1007. doi: 10.1016/j.surg.2012.08.040

Table VI.

Exon Array Results for Selected Genes of Interest from Other Studies

SBNET vs. Normal PNET vs. Normal

Gene Gene Name Fold-Change p-value Fold-change p-value
ADCY2* Adenylate Cyclase (Brain) +2.21 5.88E-05 +1.28 0.1370
PRKAR1A* Protein Kinase, cAMP-dependent, Regulatory, Type I, Alpha +1.84 9.19E-05 +1.69 0.0020
BEX1* Brain Expressed, x-Linked 1 +15.11 3.60E-08 +2.75 0.0044
BICD1* Bicaudal D Homolog (Drosophila) +1.93 0.0182 +1.18 0.4131
CHGB* Chromogranin B (secretogranin 1) +17.45 4.71E-05 +7.38 0.0008
CPE* Carboxypeptidase E +6.27 1.23E-08 +4.59 0.0016
GABRB3* Gamma-aminobutyric Acid (GABA) A Receptor, Beta 3 +4.01 6.47E-08 +2.68 0.0031
SCG2* Secretogranin II +2.61 4.52E-05 +7.98 0.0011
SCG3* Secretogranin III +7.20 1.06E-05 +5.80 0.0016
ACTG2 Actin, gamma 2, Smooth Muscle, Enteric −1.55 0.3933 +1.02 0.9551
GREM2 Gremlin 2 −1.49 0.1147 −1.27 0.0196
REG3A Regenerating Islet-Derived 3 Alpha −9.18 2.15E-05 −2.82 0.4280
TUSC2 Tumor Suppressor Candidate 2 +1.05 0.7133 −1.57 0.0065
RUNX1 Runt-Related Transcription Factor 1 −1.03 0.8191 +1.19 0.5596
TPHl Tryptophan Hydroxylase 1 +17.71 7.82E-05 +2.04 0.1128
TGFBR2 Transforming Growth Factor, Beta Receptor II −1.45 0.1322 −1.19 0.4957
CDH6 Cadherin 6, Type 2, K- Cadherin (Fetal Kidney) +5.62 1.15E-06 +2.68 0.0068
ECM1 Extracellular Matrix Protein 1 +2.86 0.0136 −1.02 0.9086
VMAT1 Solute Carrier Family 18 (Vesicular Monoamine), Member 1 +22.06 3.40E-06 −1.30 0.1677
LGALS4 Lectin, Galactoside-Binding, Soluble, 4 −3 15 0.0038 −1.99 0.1649
TSC2§ Tuberous Sclerosis 2 +1.12 0.4872 −1.24 0.0386
SSTR2§ Somatostatin Receptor 2 +1.49 0.0118 +1.62 0.0680
FGF13§ Fibroblast Growth Factor 13 +1.41 0.0003 +1.03 0.8247
FEV FEV (ETS Oncogene Family) +2.15 0.0071 −1.18 0.0263
ADCY2 Adenylate Cyclase (Brain) +2.21 5.88E-05 +1.28 0.1370
NR4A2 Nuclear Receptor Subfamily 4, Group A, Member 2 +1.13 0.6564 −2.17 0.1000
GADD45b Growth Arrest and DNA- Damage-Inducible, Beta −1.08 0.5842 −2.25 0.0016
CD302 Type Lectin Domain Family 13, Member A NA NA NA NA
PPWD1 Peptidylprolyl Isomerase Domain and WD Repeat Containing 1 +1.14 0.5971 +1.61 0.0030
ABHD14B Abhydrolase Domain Containing 14B −1.09 0.3084 −1.35 0.0064

Gray coloration indicates the primary site upon which the study noted focused. Non-shaded areas for comparison purposes from the other primary site.

*

Drozdov I, Svejda B, Gustafsson BI, Mane S, Pfragner R, Kidd M, et al. Gene network inference and biochemical assessment delineates GPCR pathways and CREB targets in small intestinal neuroendocrine neoplasia. PLoS One. 2011;6:e22457.

Edfeldt K, Bjorklund P, Akerstrom G, Westin G, Hellman P, Stalberg P. Different gene expression profiles in metastasizing midgut carcinoid tumors. Endocr Relat Cancer. 2011; 18:479–489.

§

Missiaglia E, Dalai I, Barbi S, Beghelli S, Falconi M, della Peruta M, et al. Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway. J Clin Oncol. 2010;28:245–255.

Duerr EM, Mizukami Y, Ng A, Xavier RJ, Kikuchi H, Deshpande V, et al. Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis. Endocr Relat Cancer. 2008;15:243–256.

Posorski N, Kaemmerer D, Ernst G, Grabowski P, Hoersch D, Hommann M, et al. Localization of sporadic neuroendocrine tumors by gene expression analysis of their metastases. Clin Exp Metastasis. 2011;28:637–647.