TABLE 3.
No. of isolates | Amino acid substitution(s)a yielded by the katG gene (2,447 bp) | Isoniazid result by: |
||
---|---|---|---|---|
Ion Torrentb | Hain LPA | Bactec MGIT 960 | ||
11 | S315T | Resistant | Resistant | Resistant |
5 | S315T, R463L | Resistant | Resistant | Resistant |
1 | W191R, R463L | Sensitive | Sensitive | Sensitive |
7 | Wild typea | Sensitive | Sensitive | Sensitive |
1 | R463L | Sensitive | Sensitive | Sensitive |
1 | N138H | Sensitive | Sensitive | Sensitive |
Compared to the H37Rv reference strain.
Isoniazid resistance is known to occur in the katG product at position 315 (S→T) (indicated in bold).