TABLE 2.

Mutations associated with HIV-1 drug resistance

Inhibitor and codona	Amino acid of wild-type sequence	Mutation(s) associated with drug resistanceb	Frequency of mutation in run 1/frequency of mutation in run 2 (%)c
			Plasma sample 1	Plasma sample 2	Plasma sample 3	Plasma sample 4	Strain 92UG037
Protease inhibitor
46	M	I, L	1.4/0.3			1.0/0.7
47	I	V, A			0.9/1.1	1.0/0.6
50	I	V			1.1/0.8	1.0/0.7
82	V	A, T, F, S, L	1.2/2.1
Nucleoside reverse transcriptase inhibitor
65	K	R		46.9/47.0
67	D	N	8.2/8.0	1.5/1.4	7.2/7.6	9.7/10.2	4.6/4.1
115	Y	F		1.2/0.7	1.3/1.7
184	M	V, I	0.7/1.2	66.2/65.8
215	T	Y, F		1.0/0.9
219	K	Q, E	2.2/1.7		2.8/2.9	5.7/6.1	5.5/4.9
Nonnucleoside reverse transcriptase inhibitor
101	K	E, P		1.9/2.4
103	K	N, S		38.1/38.5
181	Y	C, I, V		38.9/38.4		91.4/92.1
190	G	A, S, E		59.9/59.2		91.2/92.2
Integrase inhibitor		No mutations associated with drug resistance found
Fusion inhibitor (enfuvirtide)
42	N	T	1.2

^aAccording to HIV-1 reference strain HXB2 (GenBank accession number NC001802).

^bOnly mutations that were found at frequencies of ≥1% in at least one sample are shown.

^cFrequencies determined by two independent sequencing runs are shown.