TABLE 3.

Comparison of ECVs obtained for five antifungal agents by use of different methods

Species	No. of isolates tested	Agenta	ECV obtained by indicated method (%)b
			MIC50 + 2 dilutions	Modal MIC + 2 dilutions	Method of Turnidge et al.	Method of Kronvallc	Clustering methodc	Median for all 5 studied methods	CLSI methodd
C. albicans	656	AND	0.12 (99.7)	0.06 (84.45)	0.25 (98.5)	0.25 (95.65)	0.25 (98.63)	0.25 (98.5)	0.12 (99.7)
	659	MCF	0.06 (95.1)	0.06 (95.1)	0.06 (95.1)	0.12 (94.95)	0.06 (94.99)	0.06 (95.1)	0.03 (97.7)
	747	CAS	0.25 (98.7)	0.25 (98.7)	0.25 (98.7)	0.5 (98.99)	0.25 (98.66)	0.25 (98.7)	0.12 (99.8)
	923	AMB	1 (100)	2 00)	2 (100)	2 (100)	1 (100)	2 (100)	2 (99.8)
	915	FLC	0.25 (90.27)	0.25 (90.27)	1 (96.4)	1 (96.99)	2 (98.8)	1 (98.5)	0.5 (94.2)
C. parapsilosis	352	AND	4 (99.71)	8 (100)	8 (100)	8 (99.87)	4 (99.75)	8 (100)	4 (100)e
	392	MCF	4 (99.23)	4 (99.23)	8 (100)	8 (99.36)	4 (99.24)	4 (99.2)	4 (100)e
	490	CAS	2 (99.2)	2 (99.2)	4 (99.8)	4 (99.39)	2 (99.19)	2 (99.2)	1(98.6)e
	603	AMB	1 (99.83)	1 (99.83)	2 (100)	2 (99.92)	1 (100)	1 (99.8)	2 (99.7)
	635	FLC	0.25 (93.7)	0.25 (93.7)	0.5 (97.9)	1 (98.48)	2 (99.52)	0.5 (97.9)	0.5 (98.7)
C. tropicalis	123	AND	0.25 (96.75)	0.5 (99.2)	1 (99.2)	1 (99.59)	1 (99.18)	1 (99.2)	0.12 (98.9)
	121	MCF	0.12 (99.2)	0.12 (99.2)	0.12 (99.2)	0.25 (99.58)	0.5 (99.17)	0.12 (99.2)	0.12 (99.1)
	138	CAS	0.25 (99.3)	0.25 (99.3)	0.5 (100)	0.5 (99.64)	0.25 (99.28)	0.25 (99.2)	0.12 (99.4)
	171	AMB	2 (100)	2 (100)	2 (100)	2 (99.11)	1 (98.82)	2 (100)	2 (99.8)
	175	FLC	0.25 (96.57)	0.25 (96.57)	0.5 (97.1)	0.5 (97.31)	0.5 (97.65)	0.5 (97.2)	0.5 (93.0)
C. glabrata	174	AND	0.12 (96.55)	0.12 (96.55)	0.12 (96.55)	0.25 (97.1)	0.25 (96.55)	0.12 (96.6)	0.25 (99.4)
	174	MCF	0.06 (95.97)	0.06 (95.97)	0.06 (95.97)	0.25 (96.33)	0.06 (95.98)	0.06 (96.0)	0.03 (98.2)
	188	CAS	0.25 (98.4)	0.25 (98.4)	0.25 (98.4)	0.5 (98.65)	0.12 (93.62)	0.25 (98.4)	0.12 (98.5)
	209	AMB	2 (100)	2 (100)	2 (100)	2 (99.76)	1 (99.52)	2 (100)	2 (99.6
	208	FLC	0.25 (97.6)	0.25 (97.6)	0.25 (97.6)	0.5 (97.83)	0.12 (95.67)	0.25 (97.6)	0.5 (9800)
C. krusei	33	AND	0.25 (96.97)	0.25 (96.97)	0.25 (97.0)	0.5 (98.44)	1 (96.97)	0.25 (97.0)	0.12 (99.3)
	33	MCF	0.5 (93.94)	0.5 (93.94)	0.25 (94.0)	1 (96.83)	0.25 (93.94)	0.5 (93.9)	0.12 (97.8)
	37	CAS	1 (91.89)	1 (91.89)	2 (94.6)	4 (95.77)	1 (91.89)	1 (91.9)	0.25 (96.3)
	51	AMB	2 (100)	4 (100)	4 (100)	4 (100)	2 (100)	4 (100)	2 (99.3)
	53	FLC	32 (100)	32 (100)	64 (100)	64 (100)	16 (98.11)	32 (100)	32 (94.4)
C. orthopsilosis	33	AND	2 (100)	4 (100)	4 (100)	4 (98.46)	2 (97.06)	4 (100)	2 (100)
	33	MCF	2 (100)	2 (100)	4 (100)	4 (100)	2 (100)	2 (100)	1 (100)
	54	CAS	2 (100)	2 (100)	4 (100)	4 (100)	2 (100)	2 (100)	0.5 (100)
	90	AMB	1 (100)	1 (100)	1 (100)	1 (100)	1 (100)	1 (100)	ND
	91	FLC	0.25 (93.41)	0.25 (93.41)	1 (97.8)	0.5 (96.07)	0.25 (94.44)	0.25 (93.4)	ND

^aAND, anidulafungin; MCF, micafungin; CAS, caspofungin; AMB, amphotericin B; FLC, flucytosine; ND, not determined.

^bThe percentage shows the percentage of isolates for which the MIC is less than or equal to the ECV (μg/ml).

^cThe percentage shows the percentage of isolates for which the MIC is less than or equal to the ECV for the modeled population.

^dData are from references 18 and 20.

^eData for the C. parapsilosis complex.