TABLE 5.
Levels of association between the ML and CL phenotypes and the L. (V.) braziliensis SNP/indel haplotypes that showed an association with DLa
| Locus or loci [haplotype(s)]b | ML |
CL |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| f (count)c | f′ (count)d | RR | Pe | 95% CI | f (count)f | f′ (count)g | RR | Pe | 95% CI | |
| CHR 28/425451 [cc- (+)] | 0 (0/9) | 0.15 (4/26) | 0 | 0.28 | — | 0 (0/17) | 0.22 (4/18) | 0 | 0.058 | — |
| CHR 28/425451 [cct (+)] | 0.67 (6/9) | 0.73 (19/26) | 0.8 | 0.51 | 0.2–2.6 | 0.59 (10/17) | 0.83 (15/18) | 0.6 | 0.11 | 0.3–1.1 |
| CHR 28/425451 [cct (+), cc- (+)] | 0 (0/9) | 0.15 (4/26) | 0 | 0.28 | — | 0 (0/17) | 0.22 (4/18) | 0 | 0.058 | — |
| CHR 28/425451 [cct (+), tt- (+)] | 0.33 (3/9) | 0.58 (15/26) | 0.5 | 0.19 | 0.1–1.6 | 0.41 (7/17) | 0.61 (11/18) | 0.7 | 0.20 | 0.3–1.3 |
| CHR 24/3074 [agtaact (−)], CHR 28/425451 [cct (+)] | 0.22 (2/9) | 0.65 (17/26) | 0.2 | 0.03 | 0.06–1 | 0.47 (8/17) | 0.61 (11/18) | 0.7 | 0.31 | 0.4–1.5 |
| CHR 24/3074 [agtaact (−)], CHR 32/1356278 [gacac (+)], CHR 28/425451 [cct (+)] | 0.11 (1/9) | 0.30 (7/23) | 0.4 | 0.26 | 0.05–2.5 | 0.2 (3/15) | 0.29 (5/17) | 0.7 | 0.42 | 0.3–2 |
| CHR 24/3074 [agtaact (−)], CHR 28/195696 [cga (+)], CHR 28/425451 [cct (+)] | 0.22 (2/9) | 0.61 (16/26) | 0.3 | 0.049 | 0.06–1.1 | 0.41 (7/17) | 0.61 (11/18) | 0.7 | 0.20 | 0.3–1.3 |
See Table 4.
(+) indicates that the presence of the haplotype in L. (V.) braziliensis isolates was evaluated for associations; (−) indicates that the absence of the haplotype in L. (V.) braziliensis isolates was evaluated for associations.
f, frequency of ML isolates with the polymorphism. In parentheses is the number of ML cases presenting the L. (V.) braziliensis haplotype(s) divided by the total number of ML cases that had isolates evaluated in that particular analysis.
f′, frequency of DL and CL isolates with the polymorphism. In parentheses is the number of DL and CL cases presenting the L. (V.) braziliensis haplotype(s) divided by the total number of DL and CL cases that had isolates evaluated in that particular analysis.
Fisher's exact test.
f, frequency of CL isolates with the polymorphism. In parentheses is the number of CL cases presenting the L. (V.) braziliensis haplotype(s) divided by the total number of CL cases that had isolates evaluated in that particular analysis.
f′, frequency of DL and ML isolates with the polymorphism. In parentheses is the number of DL and ML cases presenting the L. (V.) braziliensis haplotype(s) divided by the total number of DL and ML cases that had isolates evaluated in that particular analysis.