TABLE 7.
Association between combined SNPs in L. (V.) braziliensis and risk of DL phenotype
| Combined SNP polymorphisms | f (count)a | f′ (count)b | RR | Pc | 95% CI | AFd |
|---|---|---|---|---|---|---|
| SNP24/3672c only, SNP28/196100ga, SNP28/425737ct, SNP32/1356598ca | 0.50 (4/8) | 0 (0/24) | 7 | 0.002 | 2.8–17.3 | 0.9 |
| SNP24/3672c only, SNP28/425737ct, SNP32/1356598ca | 0.75 (6/8) | 0.08 (2/24) | 9 | 0.0008 | 2.2–36.0 | 0.9 |
| SNP24/3672c only, SNP28/196100ga, SNP28/425737ct | 0.67 (6/9) | 0.19 (5/26) | 4.4 | 0.01 | 1.3–14.3 | 0.8 |
| SNP24/3672c only, SNP28/425737ct | 0.89 (8/9) | 0.27 (7/26) | 10.7 | 0.002 | 1.5–76.3 | 0.9 |
| SNP24/3672c only, SNP32/1356598ca | 0.75 (6/8) | 0.29 (7/24) | 4.4 | 0.03 | 1.0–18.4 | 0.8 |
| SNP28/196100ga, SNP28/425737ct | 0.67 (6/9) | 0.19 (5/26) | 4.4 | 0.01 | 1.3–14.3 | 0.8 |
| SNP28/425737ct, SNP32/1356598ca | 0.75 (6/8) | 0.12 (3/24) | 7.7 | 0.002 | 1.9–31.2 | 0.9 |
| SNP32/1356598ca, SNP26/909g only | 0.37 (3/8) | 0 (0/22) | 5.4 | 0.01 | 2.4–11.9 | 0.8 |
a
f, frequency of DL isolates with the polymorphism. In parentheses is the number of DL cases presenting the L. (V.) braziliensis SNPs divided by the total number of DL cases that had isolates evaluated in that particular analysis.
b
f′, frequency of ML and CL isolates with the polymorphism. In parentheses is the number of CL and ML cases presenting the L. (V.) braziliensis SNPs divided by the total number of CL and ML cases that had isolates evaluated in that particular analysis.
c
Fisher's exact test.
d
AF, fraction of DL attributable to that combination of polymorphisms.