Fig 1.

C57BL/6 STAT1^−/− mice are highly susceptible to rMA15. (A) Weight loss in WT and STAT1^−/− mice infected with either rMA15 or PBS control (n = 15 for each strain). The error bars indicate standard deviations. (B) rMA15 lung titers in WT and STAT1^−/− mice (n = 5 for each time point). The asterisk indicates a P value of <0.5, and the dashed line indicates the level of detection. (C) H&E staining of WT and STAT1^−/− mice infected with rMA15 or mock infected with PBS at 9 days p.i. (D) Histological scoring of lung sections of WT and STAT1^−/− mice infected with rMA15 or mock infected with PBS at 9 days p.i.