TABLE 1.
Nucleotides and amino acids of 10 HPV type 6 isolates in laryngeal papillomas versus the closest reference sequence
| Isolate no. | Patient characteristics |
URR metha | Closest HPV (accession no.) | Size (bp) | Accession no. | No. (%) of different nucleotides | No. of indicated mutation type foundb |
Amino acid conservationc |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age (yrs) | Sex | Smoker? | Site | Missense | Silent | Ins | Del | Ts | Tv | NC | WC | SC | ||||||
| PV2702 | 67 | F | Never | Larynx | No | HPV6b (X00203) | 7996 | JN252323 | 2 (0.03) | 0 | 3 | 1 | 0 | 0 | 2 | 0 | 0 | 0 |
| PV1499 | 43 | M | Never | Larynx | No | HPV6b (X00203) | 7996 | JN252322 | 18 (0.23) | 0 | 19 | 1 | 0 | 8 | 10 | 0 | 0 | 0 |
| PV1666 | 68 | M | Never | Larynx | NA | HPV6vc (AF09293) | 8031 | JN252316 | 4 (0.05) | 2 | 3 | 1 | 0 | 2 | 2 | 1 | 1 | 0 |
| PV2345 | 40 | M | Never | Larynx | No | HPV6vc (AF09293) | 8032 | JN252314 | 6 (0.07) | 3 | 7 | 1 | 0 | 3 | 3 | 1 | 1 | 1 |
| PV0529 | 58 | M | Quit | Pharynx | No | HPV6vc (AF09293) | 8031 | JN252315 | 30 (0.37) | 12 | 19 | 1 | 0 | 14 | 16 | 2 | 4 | 6 |
| PV1667 | 39 | M | Never | Larynx | NA | HPV6vc (AF09293) | 8029 | JN252320 | 29 (0.36) | 11 | 20 | 1 | 1 | 14 | 15 | 2 | 4 | 5 |
| PV1731 | 40 | M | Never | Larynx | NA | HPV6vc (AF09293) | 8031 | JN252317 | 29 (0.36) | 11 | 19 | 1 | 0 | 14 | 15 | 2 | 4 | 5 |
| PV1774 | 56 | M | Never | Larynx | No | HPV6vc (AF09293) | 8031 | JN252318 | 31 (0.39) | 12 | 20 | 1 | 0 | 16 | 15 | 2 | 4 | 6 |
| PV2530 | 40 | M | Never | Larynx | No | HPV6vc (AF09293) | 8031 | JN252319 | 28 (0.35) | 11 | 18 | 1 | 0 | 15 | 13 | 2 | 3 | 6 |
| PV1732 | 24 | M | Quit | Larynx | NA | HPV6a (L41216) | 8010 | JN252321 | 11 (0.14) | 4 | 7 | 0 | 0 | 8 | 3 | 3 | 0 | 1 |
a
Methylation status in the URR. NA, not analyzed.
b
Ins, insertion; Del, deletion; Ts, transition; Tv, transversion.
c
NC, nonconserved amino acid change; WC, weakly conserved amino acid change; SC, strongly conserved amino acid change.