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M250I mutation and disease progression in subtype C infections. Comparisons of the plasma viral loads and CD4+ T-cell counts between individuals infected with M250I mutants and those without in the acute infection cohort (A and B) and in the chronic cohort (C and D) are shown. The viral loads and CD4+ T-cell counts for the acute cohort were calculated as the means of three time points closest to 12 months postinfection.
