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ECTV-Δ036 but not ECTV-DsRed is severely attenuated in vivo. (A) BALB/c mice were infected with various doses of ECTV-WT, ECTV-Δ036, or ECTV-DsRed in the footpad, and survival was monitored. Experiments had 5 (left and middle) or 3 (right) mice/group. (B) Virus titers in the indicated organs of BALB/c mice (n = 3) at the indicated dpi. Each data point indicates an individual mouse (P < 0.0001 for values for all organs).
