Fig. 6.

PM progenitors form a regulatory network that coordinates early cardiogenesis and craniofacial myogenesis, (A) A summary of the genetic interactions of the PM transcriptional network and its impact on cardiogenesis and myogenesis. (B) A proposed model for a domain-specific subdivision of DGS-like anomalies in mouse models into rostral (heart and craniofacial) and caudal (arch artery) phenotypes. The model is based on the progressive alignment of the pharyngeal arches with the heart tube during its looping stages (50). The corresponding mouse knockout phenotypes are shown along these two domains.