Fig. 2.

C5aR on radiosensitive cells is necessary and sufficient for arthritis. (A and B) Arthritis in BMC of WT and C5ar^−/− mice. Clinical score and ankle thickening (AT) were assessed daily (n = 4 mice per group). WT → WT or WT → C5ar^−/− vs. C5ar^−/− → C5ar ^−/− or C5ar^−/− → WT, P < 0.001 in clinical score and in AT. (C) Histological scoring of ankles from mice in A and B. *P < 0.05 compared with C5ar^−/− → C5ar^−/−, and ^#P < 0.05 compared with C5ar^−/− → WT. (D) Respective representative sections. One representative of two independent experiments is shown. Data are presented as mean ± SEM. (Scale bars, 100 μm.)