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. 2012 Oct 29;109(46):E3177–E3185. doi: 10.1073/pnas.1213797109

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Fig. 4. — C5aR/5-LO coexpression in PMNs is required for arthritis. (A and B) A total of 20 × 10⁶ WT or C5ar^−/− PMNs were adoptively transferred into Alox5^−/− mice (“WT PMNs Alox5^−/−” and “C5ar^−/− PMNs Alox5^−/−”) together with K/BxN serum i.v. on days 0 and 2. Alox5^−/− mice receiving only K/BxN serum served as controls. Mice were clinically scored daily (n = 4–5 mice per group; one representative of three independent experiments is shown). P < 0.001 for WT PMNs Alox5^−/− vs. C5ar^−/− PMNs Alox5^−/− or Alox5^−/− controls in clinical score and ankle thickening. Data are presented as mean ± SEM.

Inline graphic — C5aR/5-LO coexpression in PMNs is required for arthritis. (A and B) A total of 20 × 10⁶ WT or C5ar^−/− PMNs were adoptively transferred into Alox5^−/− mice (“WT PMNs Alox5^−/−” and “C5ar^−/− PMNs Alox5^−/−”) together with K/BxN serum i.v. on days 0 and 2. Alox5^−/− mice receiving only K/BxN serum served as controls. Mice were clinically scored daily (n = 4–5 mice per group; one representative of three independent experiments is shown). P < 0.001 for WT PMNs Alox5^−/− vs. C5ar^−/− PMNs Alox5^−/− or Alox5^−/− controls in clinical score and ankle thickening. Data are presented as mean ± SEM.