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. 2012 Oct 29;109(46):E3177–E3185. doi: 10.1073/pnas.1213797109

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Fig. 5. — IL-1β/FcRγ coexpression in PMNs is required for arthritis. (A and B) Arthritis in WT → WT, Fcer1g^−/− → WT, Il1a^−/−Il1b^−/− → WT, Il1a^−/−Il1b^−/−/Fcer1g^−/− → WT, Il1a^−/−Il1b^−/−/WT → WT, and Fcer1g^−/−/WT → WT BMC (n = 4–5 mice per group). P < 0.0001, WT → WT, Il1a^−/−Il1b^−/−/WT → WT, and Fcer1g^−/−/WT → WT vs. Il1a^−/−Il1b^−/−/Fcer1g^−/− → WT, Il1a^−/−Il1b^−/− → WT, and Fcer1g^−/− → WT. (C) Histological score of ankles from mice in A and B (n = 7–9 mice per group; data compiled from two independent experiments). *P < 0.05, **P < 0.01 for indicated group vs. Il1a^−/−Il1b^−/−/Fcer1g^−/− → WT; ^#P < 0.05, ^##P < 0.01 for indicated group vs. Il1a^−/−Il1b^−/− → WT; ⁺P < 0.05, ⁺⁺P < 0.01, ⁺⁺⁺P < 0.001 for indicated group vs. Fcer1g^−/− → WT. (D) Respective representative sections. (Scale bars, 100 μm.) (E and F) Clinical evaluation. A total of 20 × 10⁶ WT or Fcer1g^−/− PMNs were adoptively transferred i.v. into Il1a^−/−Il1b^−/− → WT chimeras (WT PMNs Il1a^−/−Il1b^−/− → WT; Fcer1g^−/− PMNs Il1a^−/−Il1b^−/− → WT) with K/BxN serum on days 0 and 2. WT → WT and Il1a^−/−Il1b^−/− → WT chimera obtaining only K/BxN serum served as controls (n = 4 mice per group; one representative of three independent experiments is shown). P < 0.001 for WT PMNs Il1a^−/−Il1b^−/− → WT vs. Fcer1g^−/− PMNs Il1a^−/−Il1b^−/− → WT or vs. Il1a^−/−Il1b^−/− → WT chimera in clinical score and AT. All data presented are mean ± SEM.

Inline graphic — IL-1β/FcRγ coexpression in PMNs is required for arthritis. (A and B) Arthritis in WT → WT, Fcer1g^−/− → WT, Il1a^−/−Il1b^−/− → WT, Il1a^−/−Il1b^−/−/Fcer1g^−/− → WT, Il1a^−/−Il1b^−/−/WT → WT, and Fcer1g^−/−/WT → WT BMC (n = 4–5 mice per group). P < 0.0001, WT → WT, Il1a^−/−Il1b^−/−/WT → WT, and Fcer1g^−/−/WT → WT vs. Il1a^−/−Il1b^−/−/Fcer1g^−/− → WT, Il1a^−/−Il1b^−/− → WT, and Fcer1g^−/− → WT. (C) Histological score of ankles from mice in A and B (n = 7–9 mice per group; data compiled from two independent experiments). *P < 0.05, **P < 0.01 for indicated group vs. Il1a^−/−Il1b^−/−/Fcer1g^−/− → WT; ^#P < 0.05, ^##P < 0.01 for indicated group vs. Il1a^−/−Il1b^−/− → WT; ⁺P < 0.05, ⁺⁺P < 0.01, ⁺⁺⁺P < 0.001 for indicated group vs. Fcer1g^−/− → WT. (D) Respective representative sections. (Scale bars, 100 μm.) (E and F) Clinical evaluation. A total of 20 × 10⁶ WT or Fcer1g^−/− PMNs were adoptively transferred i.v. into Il1a^−/−Il1b^−/− → WT chimeras (WT PMNs Il1a^−/−Il1b^−/− → WT; Fcer1g^−/− PMNs Il1a^−/−Il1b^−/− → WT) with K/BxN serum on days 0 and 2. WT → WT and Il1a^−/−Il1b^−/− → WT chimera obtaining only K/BxN serum served as controls (n = 4 mice per group; one representative of three independent experiments is shown). P < 0.001 for WT PMNs Il1a^−/−Il1b^−/− → WT vs. Fcer1g^−/− PMNs Il1a^−/−Il1b^−/− → WT or vs. Il1a^−/−Il1b^−/− → WT chimera in clinical score and AT. All data presented are mean ± SEM.