Fig. 2.
Plasma viremia in macaques pretreated with different doses of the bnMAbs PGT121 and challenged with SHIVSF162P3. Plasma viral loads are shown for animals administered 5 mg/kg PGT121 (A), 1 mg/kg PGT121 (B), 0.2 mg/kg PGT121 (C), and 5 mg/kg DEN3 (D). Sterilizing immunity was observed for all animals given 5 mg/kg and 1 mg/kg PGT121, and in three of five animals given 0.2 mg/kg. One animal (r95090) administered 5 mg/kg PGT121 was euthanized 3 wk after challenge because of unrelated illness. Necropsy showed no sign of viral infection. All animals treated with the control antibody DEN3 became infected. The assay sensitivity limit was 150 RNA copies per mL.