Table 3.
Group | n | ARC | ILRC | IRC | ICD | NRC | CRC | AC |
---|---|---|---|---|---|---|---|---|
NC | 5 | 0.73 ± 0.20 | 0.57 ± 0.13 | −4.14 ± 0.14 | 2.51 ± 0.26 | −5.02 ± 0.19 | −5.18 ± 0.11 | 0.21 ± 0.05 |
HF | 5 | 1.61 ± 0.19* | 1.57 ± 0.22* | −5.20 ± 0.09* | 2.37 ± 0.08 | −3.99 ± 0.33* | −4.19 ± 0.12* | 0.72 ± 0.10* |
HF+S | 5 | 1.95 ± 0.11∗# | 1.93 ± 0.17∗# | −5.42 ± 0.07∗# | 1.45 ± 0.14∗# | −3.40 ± 0.14∗# | −3.84 ± 0.11∗# | 0.98 ± 0.04∗# |
HF+T+S | 5 | 1.72 ± 0.14∗★ | 1.67 ± 0.11∗★ | −5.33±0.05∗▲★ | 1.78 ± 0.12∗#∇ | −3.62 ± 0.12∗▲★ | 4.02 ± 0.07∗▲★ | 0.84 ± 0.06∗▲∇ |
ARC: AT1R mRNA relative content; ILRC: IL-1β mRNA relative content; IRC: insulin raltive concentration; ICD: insulin positive cell density; NRC: NF-κB relative concentration; CRC: caspase-3 relative concentration; AC: apoptosis cells of unit islet area.
NC: normal control group; HF: high-fat diet group; HF+S: high-fat diet plus STZ intraperitoneal injection group; HF+T+S: high-fat diet plus telmisartan intervention and STZ intraperitoneal injection group.
● P < 0.05; *P < 0.01 as compared with NC group; ▲ P < 0.05, #<0.01 as compared with HF group; ★<0.05, ∇<0.01 as compared with HF+S group.