Table 1. Inhibitory Activities of Selected Aβ(1-42) Inhibitors Towards the Formation of Aβ(25-35) Fibrils.
Aβ(25–35) |
Aβ(1–42) |
|||
---|---|---|---|---|
compd | IC50(μM)a | Aβ (μM)/ IC50 (μM) | IC50(μM)c | Aβ (μM)/ IC50 (μM) |
myricetin | 0.4 (44) | 58.1 | ||
3.0 | 32.9 | 0.3–0.542,43 | ||
2.521 | 20 | |||
curcumin | 13.0 | 7.7 | 0.6 (44) | 39.7 |
0.6–1.142,43 | ||||
(−)-tetracycline | 14.8 | 6.7 | 10.044 | 2.5 |
tacrine | /b | nonactive22 |
IC50 inhibitory concentration (μM) values are expressed as mean ±5% [standard error of the mean (SEM)] of two experiments (n = 2), each performed in duplicate.
Inactive in the concentration rage 5–500 μM.
Data taken from literature.