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. 2012 Sep 4;3(11):952–962. doi: 10.1021/cn3000982

Table 1. Inhibitory Activities of Selected Aβ(1-42) Inhibitors Towards the Formation of Aβ(25-35) Fibrils.

  Aβ(25–35)
Aβ(1–42)
compd IC50(μM)a Aβ (μM)/ IC50 (μM) IC50(μM)c Aβ (μM)/ IC50 (μM)
myricetin     0.4 (44) 58.1
  3.0 32.9 0.3–0.542,43  
      2.521 20
curcumin 13.0 7.7 0.6 (44) 39.7
      0.6–1.142,43  
(−)-tetracycline 14.8 6.7 10.044 2.5
tacrine /b   nonactive22  
a

IC50 inhibitory concentration (μM) values are expressed as mean ±5% [standard error of the mean (SEM)] of two experiments (n = 2), each performed in duplicate.

b

Inactive in the concentration rage 5–500 μM.

c

Data taken from literature.