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Cancer testis gene and associated melanoma prognostic marker.
| CTA | Thickness | Ulceration | Metastasis | RFS | Reference |
|---|---|---|---|---|---|
| NY-ESO1 | √ | √ | − | [21, 24, 25] | |
| MAGE-A1 | √ | √ | − | [21] | |
| MAGE-A4 | − | [21] | |||
| XAGE-1 | √ | [27] | |||
| MAGE-A3 | √ | +* | [23, 37] | ||
| MAGE-C1/C2 | √ | [29] |
√: the gene is associated with thicker tumors, ulcerated tumors, and metastatic tumors.
(−) A decrease in time of relapse free survival.
(+) increase in time of relapse free survival.
*Only found in stage III melanoma.
