Table 3.

Replication of ancestry and allelic association with asthma at rs1361549 in Puerto Rican cases and controls included in the GALA study. The sign of the regression coefficient indicates the direction of the effect, which is consistent between the two studies. The regression coefficient for tests of association at rs1361549 in European Americans in the CSGA/SARP was 0.066 (p=0.43). Also shown are stratified tests of association in African Americans based on local ancestry.

	Primary/Discovery Sample African Americans, CSGA/SARP:			Replication Sample Puerto Ricans, GALA:
Logistic Model	Regression Coefficient	Standard Error	p-value	Regression Coefficient	Standard Error	p-value
Local African Ancestry	0.96	0.29	7.9×10−4	0.22	0.080	5.4×10−3
rs1361549 (No Correction)	0.094	0.047	0.0472	0.01	0.036	0.79
rs1361549 (Global Ancestry Correction)	0.093	0.048	0.0527	0.007	0.036	0.85
rs1361549 (Local Ancestry Correction)	0.28	0.058	1.9×10−6	0.099	0.044	0.025
rs1361549 (2 African Chrom)	n/a	n/a	n/a	n/a	n/a	n/a
rs1361549 (1 African, 1 European/Native American)	0.25	0.059	2.5×10−5	0.19	0.11	0.073
rs1361549 (2 European/Native American)	0.35	0.12	5.4×10−3	0.068	0.050	0.18