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. 2013 Jan 1;18(1):5–18. doi: 10.1089/ars.2011.4373

FIG. 4.

FIG. 4.

Oxidative stress is increased in hearts from MAO-A overexpressing mice and participates in the development of dilated cardiomyopathy. (A) 8-OH-dG immuno-histochemistry on cardiac sections from 5-month-old NTg, Tg 61, and Clorg-treated Tg 61 (Tg 61+clorg) mice (×400). Quantification of 8-OH-dG staining was expressed as percent of total area (n=5). (B) Activity of antioxidant enzymes glutathion peroxidase (GPX), catalase (CAT), and superoxide dismutase (Mn-SOD) in ventricles from 3-month-old NTg and Tg 61 mice (n=5–6). (C) Fractional shortening (FS), left-ventricular end-systolic diameter (LVESD), and cardiomyocyte number in 5-month-old NTg, Tg 61-untreated, and N-acetyl-cystein (NAC)-treated Tg 61 (Tg61+NAC) mice (n=6) (*p<0.05, **p<0.01, ***p<0.001, §p<0.05, §§p<0.01 vs. indicated value).