Figure 2.
Dopamine release in response to pain-stress is differentially modulated by allelic variation of the rs12706832 SNP in the Leptin gene. The localization of changes in [11C]raclopride binding potential–nondisplaceable (BPND) in the ventral striatum following pain-stress as they relate to individual allelic variation in rs12706832 SNP are shown on the left. The left side of the image corresponds to the left side of the body (neurological convention), which is ipsilateral to the pain stimulus. Color scale relates to z-scores. The bar graphs illustrate the change in [11C]raclopride binding potential–nondisplaceable extracted from the right ventral striatum and left nucleus accumbens. Data are represented as mean ± SEM. *, GG > AG and AA (top right); *, GG > AA (bottom right).