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Interactions within the C-terminal tail and between the tail and the C2 domain of PTEN. Total count of hydrogen bonds within the C-terminal tail (red) and between the tail and the C2 domain (black) in membrane-bound (A) and in dissolved (B) wt PTEN. (C) Distances between AA residues, as indicated, that are engaged in salt bridge formations between the C-terminal tail (E390, D393) and the CBR3 loop of the C2 domain near the membrane binding interface of wt PTEN.
