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. Author manuscript; available in PMC: 2012 Nov 21.
Published in final edited form as: Chembiochem. 2011 Jun 10;12(11):1767–1773. doi: 10.1002/cbic.201100007

Figure 3.

Figure 3

Modulation of intracellular DCTPP1 does not modify triptolide-induced cytotoxicity. (A) DCTPP1-HA overexpression (OE) and siRNA-mediated knockdown (KD) of the overexpressed protein, quantified relative to negative control (Neg) siRNA transfection and normalized to β-actin levels. (B) Dose-response of cell number (measured by CellTiterGlo luminescence in arbitrary units, AU) after 48 hours’ exposure to the indicated triptolide concentration, in HeLa cells transiently transfected with DCTPP1-HA (OE) or vector (pCS2+) control; or (C) transfected with a negative control siRNA (Neg) or an siRNA targeting DCTPP1 (KD). IC50 = 7–10 nM.