Table 3.
Odds ratios and 95% confidence intervals for associations between RET SNPs and Hirschsprung’s disease, by race/ethnicity1,2
| SNP3 | Genotype | All subjects | Non-Hispanic white | African- American | Hispanic | Asian |
|---|---|---|---|---|---|---|
| rs10900296: G>A | GA | 1.68 (1.24, 2.27) P=8.1×10−4 | 1.85 (1.22, 2.82) P=4.0×10−3 | 1.15 (0.61, 2.17) P=6.7×10−1 | 1.97 (0.95, 4.09) P=7.0×10−2 | 2.95 (0.56, 15.69) P=2.0×10−1 |
| AA | 10.64 (7.14, 15.85) P=3.1×10−31 | 11.59 (7.08, 18.99) P=2.2×10−22 | 2.59 (0.41, 16.27) P=3.1×10−1 | 17.82 (5.83, 54.49) P=4.4×10−7 | 12.73 (2.60, 62.35) P=1.7×10−3 | |
| rs10900297: C>A | CA | 1.01 (0.67, 1.53) P=9.5×10−1 | 1.05 (0.54, 2.04) P=8.8×10−1 | 1.02 (0.52, 2.01) P=9.5×10−1 | 0.88 (0.35, 2.21) P=7.8×10−1 | - |
| CC | 2.30 (1.54, 3.44) P=4.4×10−5 | 3.03 (1.63, 5.65) P=4.9×10−4 | 0.81 (0.36, 1.83) P=6.1×10−1 | 1.97 (0.80, 4.85) P=1.4×10−1 | - | |
| rs1864410: C>A | CA | 1.83 (1.33, 2.51) P=2.2×10−4 | 1.78 (1.17, 2.71) P=6.9×10−3 | 1.47 (0.64, 3.39) P=3.7×10−1 | 2.37 (1.14, 4.94) P=2.1×10−2 | 3.37 (0.63, 18.01) P=1.6×10−1 |
| AA | 11.49 (7.55, 17.47) P=4.2×10−30 | 11.64 (7.02, 19.28) P=1.6×10−21 | - | 25.81 (7.31, 91.06) P=4.4×10−7 | 12.79 (2.61, 62.73) P=1.7×10−3 | |
| rs2435357: C>T | CT | 1.89 (1.37, 2.61) P=1.1×10−4 | 1.87 (1.22, 2.86) P=3.9×10−3 | 1.37 (0.57, 3.28) P=4.8×10−1 | 2.54 (1.23, 5.26) P=1.2×10−2 | 2.98 (0.56, 15.85) P=2.0×10−1 |
| TT | 11.43 (7.59, 17.22) P=2.1×10−31 | 11.51 (7.05, 18.80) P=1.7×10−22 | 4.16 (0.57, 30.55) P=1.6×10−1 | 21.38 (5.92, 77.23) P=3.0×10−6 | 12.57 (2.57, 61.43) P=1.8×10−3 | |
| rs1800858: G>A | GA | 1.88 (1.37, 2.58) P=1.0×10−4 | 1.89 (1.24, 2.88) P=3.0×10−3 | 1.14 (0.48, 2.70) P=7.7×10−1 | 2.83 (1.36, 5.91) P=5.6×10−3 | 2.92 (0.55, 15.51) P=2.1×10−1 |
| AA | 10.82 (7.22, 16.21) P=7.6×10−31 | 10.99 (6.73, 17.94) P=9.2×10−22 | 4.55 (0.62, 33.52) P=1.4×10−1 | 16.55 (5.24, 52.26) P=1.7×10−6 | 14.25 (2.90, 69.98) P=1.1×10−3 | |
| rs1800861: T>G | TG | 1.67 (1.26, 2.21) P=3.5×10−4 | 1.64 (1.14, 2.37) P=8.0×10−3 | 1.05 (0.53, 2.07) P=8.9×10−1 | 1.62 (1.32, 5.20) P=6.0×10−3 | 2.70 (0.51, 14.44) P=2.4×10−1 |
| GG | 2.94 (1.90, 4.55) P=1.3×10−6 | 2.51 (1.42, 4.43) P=1.5×10−3 | 1.20 (0.12, 11.92) P=8.8×10−1 | 3.95 (1.28, 12.17) P=1.7×10−2 | 6.55 (1.33, 32.15) P=2.1×10−2 | |
| rs2075912: C>T | CT | 1.83 (1.38, 2.43) P=2.9×10−5 | 1.94 (1.35, 2.79) P=3.5×10−4 | 0.81 (0.35, 1.86) P=6.1×10−1 | 2.56 (1.31, 5.01) P=6.1×10−3 | 3.40 (0.67, 17.26) P=1.4×10−1 |
| TT | 4.69 (2.81, 7.83) P=3.3×10−9 | 4.81 (2.39, 9.69) P=1.1×10−5 | 1.66 (0.15, 18.88) P=6.8×10−1 | 3.89 (1.03, 14.66) P=4.4×10−2 | 9.87 (1.97, 49.95) P=5.3×10−3 |
1
Analyses performed using logistic regression with adjustment for maternal smoking and parity (analyses that include all subjects are also adjusted for race/ethnicity)
2
Reference group is homozygous for major allele; effect estimates are for being heterozygous and homozygous for minor allele; effect estimates were not available when there were no cases or controls in a genotype group
3
Major allele is listed first