Skip to main content
. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: J Hum Genet. 2012 May 31;57(8):485–493. doi: 10.1038/jhg.2012.54

Table 4.

P values for associations between Hirschsprung’s disease and SNPs in candidate genes for enteric nervous system development, including (+) and excluding (-) cases with RET coding and splice-site variants1

Gene SNP2 All subjects Non-Hispanic white African- American Hispanic Asian
+ − + − + − + − + −
ASCL1 rs9782:A>G 0.45 0.73 0.80 0.68 0.11 0.33 0.47 0.28 0.93 0.99
rs1391682:G>A 0.70 0.71 0.67 0.58 0.98 0.98 0.75 0.66 0.88 0.75
rs2291854:C>T 0.73 0.68 0.39 0.18 0.84 0.77 0.28 0.20 0.99 0.98
rs17450122:A>G 0.97 0.88 0.86 0.60 0.029 0.0085 0.79 0.91 0.99 0.93
rs1874875:G>C 0.10 0.12 0.015 0.024 0.88 0.98 0.91 0.91 0.26 0.36
HOXB5 rs4793943:C>G 0.86 0.93 0.80 0.67 0.19 0.25 0.052 0.034 0.95 0.85
rs4793589:G>C 0.89 0.96 0.75 0.62 0.17 0.22 0.052 0.033 0.95 0.85
rs872760:T>C 0.77 0.86 0.78 0.65 0.17 0.22 0.052 0.034 0.95 0.85
rs9299:A>G 0.94 0.78 0.45 0.50 0.58 0.37 0.55 0.43 0.42 0.46
rs7406798:C>T 0.91 0.80 0.54 0.63 0.98 0.71 0.96 0.83 0.99 0.99
rs1529334:T>C 0.76 0.82 0.95 0.97 0.36 0.35 0.064 0.036 0.89 0.76
L1CAM Male
rs4646266:C>A 0.34 0.37 0.98 0.88 0.37 0.48 0.30 0.26 0.98 0.98
rs5987173:G>A 0.46 0.65 0.99 0.99 0.43 0.64 0.93 0.97 0.99 0.99
rs4646265:T>C 0.75 0.75 0.99 0.75 0.75 0.70 0.23 0.15 0.98 0.98
rs4646263:G>A 0.35 0.30 0.60 0.32 0.33 0.45 0.27 0.41 0.43 0.53
Female
rs4646266:C>A 0.60 0.90 0.52 0.59 0.57 0.82 0.96 0.70 0.99 0.99
rs5987173:G>A 0.69 0.89 0.99 0.99 0.80 0.98 0.97 0.97 0.99 0.99
rs4646265:T>C 0.18 0.0094 0.051 0.020 0.40 0.34 0.31 0.60 0.89 0.58
rs4646263:G>A 0.37 0.15 0.35 0.26 0.47 0.46 0.50 0.57 0.16 0.70
PHOX2B rs11723860:G>A 0.48 0.67 0.15 0.11 0.96 0.91 0.42 0.38 0.92 0.99
rs6826373:C>T 0.85 0.80 0.77 0.80 0.75 0.86 0.057 0.058 0.84 0.99
rs2196822:A>C 0.99 0.70 0.79 0.80 0.34 0.13 0.28 0.12 0.81 0.98
rs6811325:C>T 0.67 0.35 0.89 0.94 0.76 0.23 0.13 0.049 0.79 0.97
rs4608840:C>T 0.67 0.39 0.71 0.76 0.47 0.12 0.20 0.084 0.81 0.98
PROK1 rs12405277:A>G 0.73 0.87 0.98 0.79 0.38 0.22 0.68 0.73 0.16 0.087
rs1857512:G>A 0.21 0.61 0.34 0.55 0.55 0.76 0.46 0.40 0.91 0.75
rs4839391:G>A 0.37 0.42 0.35 0.18 0.75 0.26 0.76 0.85 0.80 0.57
rs884735:A>T 0.08 0.12 0.26 0.29 0.14 0.053 0.91 0.94 0.82 0.87
rs3795828:C>T 0.38 0.59 0.75 0.86 0.73 0.61 0.44 0.52 0.99 0.99
rs17628304:A>C 0.23 0.39 0.93 0.92 0.38 0.16 0.20 0.23 0.33 0.22
rs7534330:C>T 0.78 0.74 0.56 0.50 0.86 0.77 0.31 0.36 0.99 0.99
rs7513898:G>A 0.19 0.21 0.72 0.72 0.044 0.016 0.21 0.39 0.16 0.087
rs7514102:G>A 0.18 0.49 0.84 0.84 0.078 0.058 0.14 0.22 0.20 0.14
rs1044837:C>T 0.23 0.26 0.73 0.91 0.19 0.18 0.77 0.78 0.99 0.83
PROKR1 rs4854479:G>C 0.091 0.12 0.083 0.13 0.35 0.15 0.14 0.18 0.54 0.32
rs7570797:A>G 0.51 0.44 0.69 0.99 0.11 0.090 0.42 0.35 0.30 0.75
rs12713655:A>G 0.26 0.25 0.43 0.63 0.62 0.41 0.54 0.63 0.62 0.44
rs4627609:T>C 0.25 0.24 0.43 0.65 0.67 0.43 0.67 0.76 0.62 0.44
rs6731427:G>A 0.28 0.36 0.53 0.66 0.68 0.70 0.34 0.34 0.23 0.20
rs4854436:G>A 0.26 0.20 0.18 0.21 0.88 0.90 0.38 0.59 0.86 0.91
RET rs10900296:G>A 1.9×10−30 1.2×10−30 7.2×10−22 7.0×10−22 0.57 0.49 2.9×10−6 4.0×10−6 0.0015 0.0016
rs10900297:C>A 4.9×10−9 5.4×10−9 3.1×10−8 2.7×10−8 0.81 0.61 0.062 0.11 0.11 0.11
rs1864410:C>A 4.4×10−29 6.8×10−29 7.6×10−21 9.8×10−21 0.67 0.79 2.1×10−6 3.7×10−6 0.0022 0.0025
rs2435357:C>T 1.8×10−30 7.4×10−30 4.9×10−22 6.7×10−22 0.31 0.59 9.5×10−6 2.1×10−5 0.0016 0.0018
rs1800858:G>A 7.1×10−30 1.7×10−29 3.7×10−21 3.7×10−21 0.32 0.69 5.8×10−6 1.2×10−5 0.00075 0.00086
rs1800861:T>G 9.4×10−7 1.6×10−5 0.0014 0.010 0.98 0.78 0.0070 0.0033 0.039 0.067
rs2075912:C>T 6.8×10−10 5.1×10−9 2.0×10−6 1.9×10−5 0.80 0.50 0.0095 0.0057 0.011 0.010
1

Logistic regression was used to calculate P values from two degree-of-freedom tests comparing SNP genotypes between cases and controls; models were adjusted for maternal smoking and parity (analyses that include all subjects are also adjusted for race/ethnicity)

2

Major allele is listed first