Table 2.
Gene ontology (GO) and KEGG annotation for representative clusters of differentially expressed genes
| Cluster | Annotation | GO term (Biological Process, level 6 or 7) or KEGG pathway name | FDR p-value |
|---|---|---|---|
| 1, 3 and 4 (731 genes) |
GO |
Positive regulation of protein metabolic process |
6.0 E-3 |
| Negative regulation of cellular macromolecule biosynthetic process |
7.3 E-3 |
||
| |
Triglyceride metabolic process |
1.0 E-2 |
|
| |
Negative regulation of gene expression |
1.0 E-2 |
|
| |
Proteolysis involved in cellular protein catabolic process |
1.0 E-2 |
|
| |
Negative regulation of kinase activity |
1.5 E-2 |
|
| |
Regulation of transcription, DNA-dependent |
2.1 E-2 |
|
| |
Protein phosphorylation |
3.3 E-2 |
|
| |
Antigen receptor-mediated signaling pathway |
3.3 E-2 |
|
| |
Regulation of phosphate metabolic process |
3.4 E-2 |
|
| |
Regulation of kinase activity |
3.4 E-2 |
|
| |
Regulation of I-kappaB kinase/NF-kappaB cascade |
3.5 E-2 |
|
| KEGG |
Ubiquitin mediated proteolysis |
1.0 E-2 |
|
| |
Sphingolipid metabolism |
1.8 E-2 |
|
| |
PPAR signaling pathway |
2.4 E-2 |
|
| |
Fatty acid metabolism |
4.6 E-2 |
|
| |
Peroxisome |
5.0 E-2 |
|
| 2 (557 genes) |
GO |
Monosaccharide catabolic process |
2.5 E-2 |
| DNA dependent DNA replication |
3.6 E-3 |
||
| |
Hexose metabolic process |
1.1 E-2 |
|
| |
Glucose metabolic process |
1.4 E-2 |
|
| |
|
Regulation of cell shape |
1.5 E-2 |
| |
|
DNA replication |
1.5 E-2 |
| |
|
Nucleoside triphosphate metabolic |
2.3 E-2 |
| |
KEGG |
Glycolysis / Gluconeogenesis |
4.9 E-4 |
| |
|
Citrate cycle (TCA cycle) |
8.9 E-4 |
| 6 (402 genes) |
KEGG |
Steroid biosynthesis |
4.4 E-3 |
| |
Glyoxylate and dicarboxylate metabolism |
1.2 E-2 |
|
| |
|
Pyruvate metabolism |
3.3 E-2 |
| 5 and 7 (250 genes) |
GO |
Enzyme linked receptor protein signaling pathway |
9.7 E-3 |
| Regulation of cellular protein metabolic process |
3.1 E-2 |
||
| |
|
Negative regulation of macromolecule metabolic process |
3.5 E-2 |
| |
|
Transmembrane receptor protein serine/threonine kinase signaling pathway |
3.6 E-2 |
| |
|
Negative regulation of protein metabolic process |
3.7 E-2 |
| |
|
Positive regulation of cellular metabolic process |
4.4 E-2 |
| |
KEGG |
PPAR signaling pathway |
1.0 E-4 |
| |
|
Glycerolipid metabolism |
1.8 E-2 |
| MAPK signaling pathway | 4.6 E-2 |