Table 3.
Shared effects of fasting and insulin-neutralization on differential gene expression
| Gene symbol | Gene title | Fold change Insu-Neu vs. Fed | Fold change Fasting vs. Fed |
|---|---|---|---|
|
Up-regulated genes | |||
| PDK4 |
pyruvate dehydrogenase kinase, isozyme 4 |
7.06 |
17.28 |
| AOX1 |
aldehyde oxidase 1 |
2.94 |
6.66 |
| PLEKHH2 |
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 |
2.41 |
2.77 |
| FBXO8 |
F-box protein 8 |
2.09 |
4.15 |
| AGTR1 |
angiotensin II receptor, type 1 |
2.04 |
4.15 |
| PCMTD1 |
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 |
1.99 |
2.25 |
| PSME4 |
proteasome (prosome, macropain) activator subunit 4 |
1.97 |
3.86 |
| ICA1 |
islet cell autoantigen 1, 69 kDa |
1.85 |
2.8 |
| IP6K2 |
inositol hexakisphosphate kinase 2 |
1.77 |
2.75 |
| UHRF2 |
ubiquitin-like, containing PHD and RING finger domains, 2 |
1.72 |
1.89 |
| ACBD5 |
acyl-Coenzyme A binding domain containing 5 |
1.72 |
2.51 |
| LOC417776 |
similar to hypothetical protein |
1.62 |
1.84 |
| CTSL2 |
cathepsin L2 |
1.54 |
2.09 |
| ZNF217 |
zinc finger protein 217 |
1.54 |
2.6 |
| IFNAR1 |
Interferon (alpha, beta and omega) receptor 1 |
1.52 |
3.47 |
|
Down-regulated genes | |||
| DGAT2 |
diacylglycerol O-acyltransferase homolog 2 (mouse) |
6.1 |
10.5 |
| EEPD1 |
endonuclease/exonuclease/phosphatase family domain containing 1 |
2.4 |
2.17 |
| ANKRD9 |
ankyrin repeat domain 9 |
2.19 |
1.98 |
| DLST |
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex |
1.95 |
1.76 |
| PTP4A3 |
protein tyrosine phosphatase type IVA, member 3 |
1.8 |
2.3 |
| HSPA5 |
heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa) |
1.76 |
1.74 |
| NOLA2 |
nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs) |
1.73 |
1.57 |
| MST1R |
macrophage stimulating 1 receptor (c-met-related tyrosine kinase) |
1.71 |
2.2 |
| GRAMD2 |
GRAM domain containing 2 |
1.69 |
2.37 |
| DHDDS |
dehydrodolichyl diphosphate synthase |
1.63 |
1.58 |
| DYNLL2 |
dynein, light chain, LC8-type 2 |
1.6 |
2.52 |
| CDT1 |
chromatin licensing and DNA replication factor 1 |
1.57 |
1.51 |
| FAHD1 |
fumarylacetoacetate hydrolase domain containing 1 |
1.56 |
1.61 |
| DOT1L |
DOT1-like, histone H3 methyltransferase (S. cerevisiae) |
1.56 |
1.82 |
| BTBD11 | BTB (POZ) domain containing 11 | 1.55 | 1.71 |
FDR p-value <0.05.