Table 1.
Association of B, E, R, T mRNA expression with clinicopathologic parameters of NSCLC
| |
|
BRCA1 |
ERCC1 |
RRM1 |
TYMS |
||||
|---|---|---|---|---|---|---|---|---|---|
| N | median | range | median | range | median | range | median | range | |
|
All tumors# |
|
36.88 |
23.13−14.34 |
39.30 |
23.13−14.95 |
38.57 |
19.54−14.02 |
36.76 |
23.85−40.25 |
|
Gender | |||||||||
| Men |
222 |
37.09 |
23.13−40.34 |
39.30 |
23.13−14.95 |
38.57 |
19.54−14.02 |
36.76 |
23.85−40.25 |
| Women |
54 |
36.24 |
32.95−39.22 |
38.22 |
35.81−40.87 |
37.95 |
30.60−41.94 |
36.51 |
30.99−39.88 |
|
P |
|
0.0053 |
0.0169 |
0.3615 |
0.4391 |
||||
|
Smoking | |||||||||
| Never |
29 |
36.16 |
27.80−39.06 |
39.01 |
27.58−40.45 |
38.19 |
19.54−41.23 |
36.45 |
32.33−39.07 |
| Former |
26 |
36.21 |
32.13−39.68 |
38.84 |
23.13−40.67 |
38.16 |
23.13−43.02 |
36.00 |
32.63−40.25 |
| Current |
150 |
37.08 |
32.34−40.34 |
39.36 |
32.27−41.95 |
38.84 |
23.34−43.02 |
36.00 |
32.63−40.25 |
|
P |
|
0.0017 |
0.2694 |
0.1541 |
0.0146 |
||||
|
Histology |
|
|
|
|
|
|
|
|
|
| Adeno |
159 |
36.38 |
23.13−39.24 |
38.83 |
23.13−41.95 |
38.04 |
20.76−41.60 |
36.12 |
30.70−39.36 |
| SCC |
70 |
37.90 |
33.94−40.34 |
93.76 |
35.40−41.23 |
39.80 |
19.83−43.02 |
37.50 |
23.85−40.20 |
| LCC/undiff |
47 |
37.33 |
30.15−39.98 |
39.11 |
29.58−40.89 |
38.33 |
19.54−42.38 |
37.21 |
31.59−40.25 |
|
P |
|
<0.0001 |
<0.0001 |
<0.0001 |
<0.0001 |
||||
|
Stage | |||||||||
| I & II |
53 |
37.16 |
23.13−40.34 |
39.16 |
23.13−41.13 |
38.52 |
22.49−43.02 |
36.79 |
23.85−40.20 |
| IIIA |
34 |
37.60 |
34.74−39.96 |
39.70 |
36.22−41.23 |
39.30 |
30.60−42.26 |
37.48 |
31.89−40.20 |
| IIIB & IV |
137 |
36.61 |
27.80−39.68 |
39.26 |
27.58−41.95 |
38.54 |
19.54−42.38 |
36.57 |
30.99−40.25 |
| P | 0.0064 | 0.5083 | 0.2249 | 0.1006 | |||||
Notes to Table 1: Medians and range represent RQ values that are expressed as (40-dCT); p = Mann Whitney Asymptotic significance for gender and Kruskal-Wallis for the rest; # = the number of tumors with informative BRCA1 RQ values was 274, and for all other genes 276; undiff = undifferentiated; SCC = squamous cell, and LCC = large cell carcinoma; stage = stage at initial diagnosis.