Table 4.

Univariate Cox regression analysis for B, E, R, T RQ values according to progression free and overall survival

	aberrant vs. normal	Progression free survival					Overall survival
		Total N	Events	HR	95% C.I.	Wald’s p	Total N	Events	HR	95% C.I.	Wald’s p
Subgroup A	BRCA1	51 vs. 100	44 vs. 79	1.307	0.901-1.897	0.158	51 vs. 102	35 vs. 62	1.019	0.672-1.545	0.930
	ERCC1	43 vs. 110	36 vs. 88	1.224	0.829-1.806	0.309	44 vs. 111	30 vs. 68	1.169	0.760-1.799	0.478
	RRM1	58 vs. 95	49 vs. 75	1.348	0.936-1.939	0.108	59 vs. 96	42 vs. 56	1.141	0.760-1.715	0.524
	TYMS	78 vs. 75	63 vs. 61	0.849	0.593-1.216	0.373	79 vs. 76	50 vs. 48	0.871	0.583-1.302	0.500
Subgroup B	BRCA1	58 vs. 113	49 vs. 87	1.313	0.921-1.872	0.132
	ERCC1	50 vs. 123	41 vs. 96	1.251	0.867-1.805	0.232
	RRM1	66 vs. 107	55 vs. 82	1.371	0.971-1.935	0.073
	TYMS	87 vs. 86	68 vs. 69	0.922	0.656-1.297	0.642
Subgroup C	BRCA1						62 vs. 123	38 vs. 67	1.003	0.672-1.499	0.987
	ERCC1						53 vs. 134	32 vs. 74	1.02	0.672-1.548	0.926
	RRM1						73 vs. 114	45 vs. 61	1.059	0.718-1.562	0.772
	TYMS						95 vs. 92	56 vs. 50	1.027	0.699-1.509	0.892

Subgroup A: 1st line, chemo-naïve; Subgroup B: 1st line, chemo-naïve and pre-treated; Subgroup C: chemo-naïve, 1st line and non-relapsed adjuvant; empty cells: not-applicable.