TABLE I.
Accuracy of her2 testing with chromogenic in situ hybridization using liquid-based cytology samples taken from breast tumours
|
Reference
|
||||
|---|---|---|---|---|
| Sumiyoshi et al., 200616 | Sartelet et al., 200517 | Vocaturo et al., 200618 | Almeida and Correia, 200819 | |
| Samples (n) | 58 | 103 | 53 | 36 |
| Fixative | 95% Ethanol | ThinPrepa | ThinPrepa | Not specified |
| Ethanolb | ||||
| Antibody | A0485 | NCL-CB11c | A0485 | A0485 |
| HercepTestd | HercepTestd | HercepTestd | ||
| Sensitivity [% (95% ci)]e | 84.00 | 100 | 85 (73 to 95) | |
| Specificity [% (95% ci)]e | 87.90 | 96% (92.0 to 99.9) | 100 | Concordance rate 94% (cytology samples vs. histology samples) |
| Predictive value [% (95% ci)] | ||||
| Positive | — | 86.40 | 100 (79 to 93) | |
| Negative | — | 100 | 92 (86 to 98) | |
| Accuracy (%) | 86.20 | — | — | |
a
Contains methanol (Cytyc, Boxborough, Massachusetts, U.S.A.).
b
Samples were post-fixed in absolute ethanol.
c
Novocastra Laboratories, Newcastle Upon Tyne, U.K.
d
Dake, Glostrup, Denmark.
e
Compared with formalin-fixed, paraffin-embedded tissue sections.