TABLE II.
Concordance between her2 status of core-needle biopsy (cnb) and corresponding surgical (ex) samples in recent studies
|
Reference
|
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|---|---|---|---|---|---|---|---|---|
| Arnedos et al.,200926 | Tamaki et al., 201028 | D’Alfonso et al., 201029 | Apple et al., 200930 | Apple et al., 200930 | Park et al., 200931 | Lebeau et al., 201032 | Lee et al., 201233 | |
| Samples tested (n) | 327 | 353 | 100 (patients) | 260 | 260 | 104 (patients) | 500 | 300 |
| Testing method | ihc | ihc | fish | fish | ihc | ihc | ihc | ihc/fish |
| Overall concordance (%) | 98.8 | 89.3 | 87 | 92 | 98 | 86.5 | 90.4 | 98 |
| Concordant her2− [n (%)] | 283 (86.5) | 182 (96.8) | 12 (85.7)a 58 (90.6)b |
102 (82) | 83 (66) | — | 411 (97.4) | 261 (100) |
| Concordant her2+ [n (%)] | 40 (12.2) | 12 (75.0) | 100 | 13 (10) | 6 (5) | — | 27 (81.8) | 33 (97.0) |
| Overall discordance (%) | — | 10.66 | 13 | 8 | 2 | — | — | 2 |
| Discordant (cnb+/ex−) [n (%)] | 1 | 0 | 2 (2) | 6 (5) | 0 (0) | 2 | 5 (15.2) | 0 (0) |
| Discordant (cnb−/ex+) [n (%)] | 3 | 0 | 2 (2) | 4 (3) | 3 (2) | 1 | 0 (0) | 6 (2) |
| Indeterminate [n (%)] | 4 (1.2) | — | — | 0 (0) | 33 (26) | — | — | — |
a
Scored as ihc 0.
b
Scored as ihc 1+.
ihc = immunohistochemistry; fish = fluorescence in situ hybridization.