Table 1.

Clinical groups for first-line treatment stratification

group	clinical presentation
0	clearly R0-resectable liver and/or lung metastases
1	unresectable liver and/or lung metastasis potentially resectable after downsizing, comorbidities allowing surgery
2	multiple metastasis, rapid progression, risk of rapid deterioration, unlikely to become resectable
3	never resectable and no symptoms or risk of deterioration