Table 1.
Summary of treatment schedules and Antp-p21/chemotherapy combinations
| Study No | Tumour | Group | Antp-p21 dose | Chemotherapy dose | PBS | Schedule |
|---|---|---|---|---|---|---|
| 1 |
Ovarian (SKOV3) |
1 |
20 mg/kg |
No |
No |
1 per week for 5 weeks |
| 1 |
Ovarian (SKOV3) |
2 |
|
Cis-Pt[2.5 mg/kg]; Taxol [10 mg/kg] |
No |
1 per week for 5 weeks |
| 1 |
Ovarian (SKOV3) |
3 |
20 mg/kg |
Cis-Pt[2.5 mg/kg]; Taxol [10 mg/kg] |
No |
1 per week for 5 weeks |
| 1 |
Ovarian (SKOV3) |
4 |
No |
No |
Yes |
1 per week for 5 weeks |
| 2 |
Colon (RKOE6) |
1 |
20 mg/kg |
No |
No |
1 per week for 5 weeks |
| 2 |
Colon (RKOE6) |
2 |
|
5FU [2 mg/kg] LV [1 mg/kg] OxPt [0.2 mg/kg] |
No |
1 per week for 5 weeks |
| 2 |
Colon (RKOE6) |
3 |
20 mg/kg |
5FU [2 mg/kg] LV [1 mg/kg] OxPt [0.2 mg/kg] |
No |
1 per week for 5 weeks |
| 2 |
Colon (RKOE6) |
4 |
No |
No |
Yes |
1 per week for 5 weeks |
| 3 |
Colon (RKOE6) |
1 |
20 mg/kg |
No |
No |
1 per day (Mon-Fri) for 4 weeks |
| 3 |
Colon (RKOE6) |
2 |
|
5FU [2 mg/kg] LV [1 mg/kg] OxPt [0.2 mg/kg] |
No |
Chemo M,W F for 4 weeks |
| 3 |
Colon (RKOE6) |
3 |
20 mg/kg |
5FU [2 mg/kg] LV [1 mg/kg] OxPt [0.2 mg/kg] |
No |
1 per day (Mon-Fri) for 4 weeks Chemo M,W F |
| 3 |
Colon (RKOE6) |
4 |
No |
No |
Yes |
1 per day (Mon-Fri) for 4 weeks |
| 4 |
Colon (Colo205) |
1 |
20 mg/kg |
No |
No |
1 per day (Mon-Fri) for 4 weeks |
| 4 |
Colon (Colo205) |
2 |
|
5FU [2 mg/kg] LV [1 mg/kg] OxPt [0.2 mg/kg] |
No |
Chemo M,W F for 4 weeks |
| 4 |
Colon (Colo205) |
3 |
20 mg/kg |
5FU [2 mg/kg] LV [1 mg/kg] OxPt [0.2 mg/kg] |
No |
1 per day (Mon-Fri) for 4 weeks Chemo M,W F |
| 4 | Colon (Colo205) | 4 | No | No | Yes | 1 per day (Mon-Fri) for 4 weeks |
Treatment studies, doses and schedules.