Table 5.
The relationship between the IGF-1R, IGF2R, ERα and ERβ protein expression and clinico-pathological features of endometrioid adenocarcinoma
| Clinical pathology | n |
ERα |
ERβ |
IGF-1R |
IGF-2R |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| Positive (%) | Strong positive(%) | Positive (%) | Strong positive(%) | Positive (%) | Strong positive(%) | Positive (%) | Strong positive(%) | |||
| Surgico-pathological stage |
I |
45 |
40(88.9) |
19(42.2) |
45(100) |
43(95.6) |
39(86.7) |
7(15.6) |
11(24.4) |
5(11.1) |
| II |
19 |
14(73.7) |
0(0) |
18(94.7) |
13(68.4) |
17(89.5) |
10(52.6) |
2(10.5) |
0(0) |
|
| III |
16 |
5(31.3) |
0(0) |
15(93.8) |
16(100) |
16(100) |
15(93.8) |
2(12.5) |
0(0) |
|
|
x2 |
18.935 |
7.334 |
3.388 |
3.225 |
3.886 |
31.727 |
2.316 |
2.544 |
||
|
P value |
0.000 |
0.013 |
0.184 |
0.237 |
0.143 |
0.000 |
0.314 |
0.291 |
||
| Histological grade |
G1 |
21 |
21(100) |
9(42.8) |
21(100) |
21(100) |
13(61.9) |
4(19.1) |
10(47.6) |
5(23.8) |
| G2 |
45 |
33(73.3) |
10(22.2) |
45(100) |
38(84.4) |
45(100) |
15(33.3) |
4(19.1) |
0(0) |
|
| G3 |
14 |
5(35.7) |
0(0) |
13(92.9) |
13(92.9) |
14(100) |
13(92.9) |
1(7.1) |
0(0) |
|
|
x2 |
21.663 |
2.543 |
3.547 |
3.844 |
24.103 |
20.972 |
13.974 |
2.689 |
||
|
P value |
0.000 |
0.447 |
0.170 |
0.163 |
0.000 |
0.000 |
0.001 |
0.304 |
||
| Depth of myometrial invasion |
≤1/2 |
58 |
53(91.4) |
13(22.47) |
56(96.6) |
51(87.9) |
50(86.2) |
14(24.1) |
11(19.0) |
5(8.6) |
| >1/2 |
22 |
6(27.3) |
6(27.3) |
22(100) |
21(95.5) |
22(100) |
18(81.8) |
4(18.2) |
0(0) |
|
|
x2 |
33.853 |
3.345 |
0.006 |
0.102 |
2.013 |
22.111 |
0.000 |
1.015 |
||
| P value | 0.000 | 0.264 | 0.936 | 0.845 | 0.156 | 0.000 | 1.000 | 0.933 | ||