Table 3.
Disease-related characteristics of the COPD patients according to anxiety or depression status
| |
Anxiety status |
pValue |
Depression status |
pValue |
||
|---|---|---|---|---|---|---|
| Yes (n = 201) | No (n = 899) | Yes (n = 393) | No (n = 707) | |||
| HADS-A score (mean, sd) |
10.4(3.1) |
3.5(2.1) |
<0.05 |
NA |
NA |
NA |
| HADS-D score (mean, sd) |
NA |
NA |
NA |
10.5(3.6) |
4.1(3.3) |
<0.05 |
| BMI (kg/m2) (mean, sd) |
22.5(2.7) |
23.7(2.8) |
<0.05 |
23.4(2.9) |
22.2(3.0) |
<0.05 |
| FEV1 (L) |
1.29(0.35) |
1.30(0.33) |
>0.05 |
1.25(0.34) |
1.29(0.35) |
<0.05 |
| 6MWD (m) (mean, sd) |
408.5(78.6) |
456.8 (95.5) |
<0.05 |
401.5(88.5) |
460.6(100.5) |
<0.05 |
| MRC score (mean, 5th-95th) |
2(0–4) |
1(0–2) |
<0.05 |
2(0–4) |
1(0–2) |
<0.05 |
| BODE index (mean, 5th-95th) |
4(1–8) |
2.5(1–6) |
<0.05 |
3.5(1–8) |
2.5(1–6) |
<0.05 |
| SGRQ score (mean, 5th-95th) | ||||||
| Symptom |
72.5(19.5) |
63.5(21.0) |
<0.05 |
70.0(17.5) |
62.0(18.7) |
<0.05 |
| Activity |
66.3(16.8) |
48.0(18.4) |
<0.05 |
61.3(17.5) |
47.8(19.5) |
<0.05 |
| Effect |
56.6(18.2) |
32.0(15.4) |
<0.05 |
48.0(18.6) |
30.7(18.8) |
<0.05 |
| Total |
61.5(17.3) |
40.6(16.4) |
<0.05 |
55.3(16.2) |
40.4(17.8) |
<0.05 |
| COPD severity (Percentage%) | ||||||
| I |
14(7.0) |
149(16.6) |
<0.05 |
25(6.4) |
138(19.5) |
<0.05 |
| II |
70(34.8) |
390(43.4) |
<0.05 |
118(30.0) |
342(48.4) |
<0.05 |
| III |
65(32.3) |
224(24.9) |
<0.05 |
123(31.3) |
166(23.5) |
<0.05 |
| IV |
52(25.9) |
136(15.1) |
<0.05 |
127(32.3) |
61(8.6) |
<0.05 |
| Comorbid anxiety |
NA |
NA |
NA |
165(42.0) |
36(5.1) |
<0.05 |
| Comorbid depression |
145(72.1) |
248(27.6) |
<0.05 |
NA |
NA |
NA |
| Female sex | 41(20.4) | 232(25.8) | <0.05 | 112(28.5) | 161(22.7) | <0.05 |
HADS: Hospital Anxiety and Depression Scale: HADS-A: HADS—anxiety; HADS-D: HADS—depression; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; BMI:body mass index; 6MWD: six-minute walking distance; MRC: Medical Research Council; SGRQ: Saint George’s Respiratory Questionnaire: BODE: body mass index, degree of airway obstruction, dyspnea and exercise capacity; Possible anxiety (8 ≤ HADS-A ≤ l0) and probable anxiety (HADS-A ≥ 11) were combined and referred to as anxiety (HADS-A ≥ 8). Possible depression (8 ≤ HADS-D ≤ l0) and probable depression (HADS-D ≥ 11) were combined and referred to and as depression (HADS-D ≥ 8).