Table 3. Details of meta-analyses in the identified reports of genes with a moderate level of evidence.
| Gene | Cohort | N | OR | CI | P-value | Meta Analysis Statistics | HeterogeneityMeasure | Statistic test | Software | Reference |
| ASPN | Meta-analysis | 2408 | 1.70 | 1.35–2.20 | 0.000013 | Random-effect model | − | − | MIX | Song et al (2008) |
| Japanese | 1353 | 1.78 | 1.26–2.51 | 0.00087 | ||||||
| Chinese | 1055 | 1.66 | 1.17–2.35 | 0.0039 | ||||||
| COL11A1 | Combined | 1722 | 1.42 | 1.23–1.65 | 0.0000033 | − | − | X2 | − | Mio et al (2007) |
| GDF5 | Meta-analysis | 5259 | 1.72 | 1.15–2.57 | 0.008 | Fixed-effects model | Not significant(Q statistics and I2) | Logistic regression model | R | Williams et al (2011) |
| SKT | Meta-analysis | 2264 | 1.34 | 1.14–1.58 | 0.00040 | Mantel-Haenszel | Japanese+Finnish:p-value = 0.27 | Logistic regression testand X2 | Haploview 4.0 and Microsoft Excel | Karasugi et al (2009) |
| Japanese A+B | 1758 | 1.31 | 1.11–1.55 | 0.0015 | Japanese A+B:p-value = 0.67 | |||||
| Finnish | 506 | 2.81 | 1.09–7.24 | 0.026 | ||||||
| THBS2 | Combined | 1743 | 1.38 | 1.21–1.58 | 0.0000028 | − | − | Kruskal-Wallis and X2 | − | Hirose et al (2008) |
| Japanese A | 1089 | 1.43 | 1.20–1.70 | 0.000040 | ||||||
| Japanese B | 654 | 1.30 | 1.05–1.62 | 0.018 | ||||||
| MMP9 | Combined | 1743 | 1.29 | 1.12–1.48 | 0.00049 | − | − | Kruskal-Wallis and X2 | − | Hirose et al (2008) |
| Japanese A | 1089 | 1.32 | 1.10–1.58 | 0.0023 | ||||||
| Japanese B | 654 | 1.23 | 0.98–1.55 | 0.077 |
CI = 95% confidence interval, N = total number of individuals in the study. Dash (−) indicates missing information in the report.