Table 2. Novel SLC26A4 variants found in Chinese hearing loss population.

No.	Variants	Exon	Amino Acid	TM Domain
Variants in exons
1	c.43_44insG	2	FS 15,stop at 86	NH2
2	c.68C>A	2	p.S23X	NH2
3	c.87G>C	2	p.E29D	NH2
4	c.234_235delC	3	FS79,stop at 96	NH2
5	c.249G>A	3	p.W83X	NH2
6	c.279T>A	3	p.S93R	NH2
7	c.665G>T	6	p.G222V	TM5
8	c.757A>G	6	p.I253V	EC LOOP 3
9	c.941C>T	8	p.S314L	TM7
10	c.1019_1020delT	9	FS 341,stop at 343	EC LOOP 4
11	c.1124A>G	9	p.Y375C	IC LOOP 4
12	c.1240G>A	10	p.E414K	EC LOOP 5
13	c.1245C>A	10	p.S415R	EC LOOP 5
14	c.1299_1300insC	11	FS 434,stop at 467	TM10
15	c.1327G>C	11	p.E443Q	IC LOOP 5
16	c.1409G>A	12	p.R470H	EC LOOP6
17	c.1472T>C	13	p.I491T	TM12
18	c.1517T>G	13	p.L506R	COOH
19	c.1595G>T	14	p.S532I	COOH
20	c.1645_1646insA	15	FS 549,stop at 563	COOH
21	c.1678G>A	15	p.D560H	COOH
22	c.1733_1735delATA	16	N579 lost, stop at 780	COOH
23	c.1897G>A	17	p.E633K	COOH
24	c.1979T>G	17	p.L660R	COOH
25	c.1983C>A	17	p.D661E	COOH
26	c.1985G>A	17	p.C662Y	COOH
27	c.1988G>A	17	p.G663E	COOH
28	c.1993A>G	17	p.I665V	COOH
29	c.2044G>T	18	p.E682X	COOH
30	c.2176A>G	19	p.I726V	COOH
31	c.2228T>A	19	p.L743X	COOH
32	c.2326C>G	21	p.R776G	COOH
Variants in spicing site
33	IVS4+2T>C (415+2T>C)	intron4	Spicing site
34	IVS13+5G>A (1544+5G>A)	intron13	Spicing site
Variant in UTR
35	2343+69C>A	21
Silent variants
36	c.225C>G	3	p.L75L	NH2
37	c.678T>C	6	p.A226A	TM5
38	c.1905G>A	17	p.E635E	COOH
39	c.2205T>G	19	p.S735S	COOH
40	c.2217A>G	19	p.Q739Q	COOH
41	c.2283A>G	20	p.T761T	COOH
Variants in introns
42	intron4-12T>A	intron4
43	intron7+(44_46delACA)	intron7
44	intron9-(28_35)delTTTGTAGG	intron9
45	intron 12-(7_13)insT	intron12
46	intron18-(53_56)delCAAA	intron18
47	intron19-25T>A	intron19

FS:frameshift;X:stop codon;del:delete.