Table II.

ORs and 95% CI for the CTLA-4 +49A/G polymorphism for different genetic models in patients with Graves’ disease.

Genetic model	Population	Pooled OR	(95% CI)	P-value	Heterogeneity P-value	Begg’s test P-value	Egger’s test P-value
Additive (G vs. A)	Asian	1.347	(1.203–1.507)	<0.001	0.003	0.323	0.373
	Caucasian	1.543	(1.324–1.798)	<0.001	<0.001	0.426	0.788
	Others	1.458	(1.157–1.837)	0.001	0.845	0.174	0.505
	Overall	1.443	(1.319–1.578)	<0.001	<0.001	0.255	0.642
Recessive (G/G vs. A carriers)	Asian	1.476	(1.267–1.721)	<0.001	0.003	0.621	0.506
	Caucasian	1.770	(1.386–2.260)	<0.001	<0.001	0.791	0.586
	Others	1.487	(0.931–2.376)	0.097	0.773	0.174	0.275
	Overall	1.589	(1.396–1.808)	<0.001	<0.001	0.978	0.965
Dominant (G carriers vs. A/A)	Asian	1.431	(1.227–1.670)	<0.001	0.349	0.187	0.196
	Caucasian	1.727	(1.419–2.102)	<0.001	<0.001	0.344	0.860
	Others	1.739	(1.254–2.412)	0.001	0.850	1.000	0.705
	Overall	1.621	(1.430–1.837)	<0.001	0.001	0.113	0.166