Table 2. Performance of the four homology models against the three AR subtypes.
A1 | A2A | A3 | |||||
MODEL | A/Ta | % | A/T | % | A/T | % | Round |
A | 1/15 | 7% | 5/15 | 33% | 7/15 | 47% | 1 |
B | 5/12 | 42% | 7/12 | 58% | 4/12 | 33% | 2 |
C | 0/6 | 0% | 0/6 | 0% | 0/6 | 0% | 3 |
D | 2/6 | 33% | 3/6 | 50% | 3/6 | 50% | 3 |
S b | 8/39 | 21% | 15/39 | 38% | 14/39 | 36% |
number of actives (A) over number of molecules tested (T).
sum: overall hit rate for all tested ligands.