Table III.
Multivariate analysis results of factors affecting recurrence risk in all enrolled patients.
| Categories (variables) | No. of recurrence-free patients/Total no. of patients (%) | Multivariate analysis HR (95% CI) (p) |
|---|---|---|
| Age | 0.74 | |
| <65 years | 23/42 (54.7) | 0.77 (0.60–1.43) |
| ≥65 years | 16/30 (53.3) | 0.62 (0.15–1.16) |
| Gender | 0.71 | |
| Male | 38/70 (54.2) | 1.00 (0.18–1.55) |
| Female | 1/2 (50.0) | 1.21 (0.75–1.16) |
| Number of recurrences/year | 0.25 | |
| 1 | 5/8 (62.5) | 0.99 (0.12–1.67) |
| 2 | 6/15 (40.0) | 0.74 (0.10–1.19) |
| ≥3 | 28/49 (57.1) | 1.15 (0.47–2.00) |
| Diameter of lesions | 0.89 | |
| <3 cm | 29/44 (65.9) | 1.01 (0.15–1.23) |
| ≥3 cm | 10/28 (35.7) | 2.21 (2.10–3.02) |
| Grade | 0.09 | |
| G1 | 3/8 (37.5) | 0.97 (0.12–1.13) |
| G2 | 16/26 (61.5) | 1.10 (0.23–1.24) |
| G3 | 20/38 (52.6) | 1.99 (0.78–2.32) |
| Number of lesions | 0.03 | |
| 1 | 10/11 (90.9) | 0.62 (0.24–1.08) |
| 2 | 13/25 (52.0) | 1.29 (0.61–1.99) |
| ≥3 | 16/36 (44.4) | 4.22 (2.62–3.95) |
| IL-6 levels | 0.62 | |
| Normal (≤3.12 pg/ml) | 21/37 (56.7) | 1.68 (1.50–2.87) |
| Abnormal | 18/35 (51.4) | 1.12 (0.20–2.12) |
| IL-10 levels | 0.71 | |
| Normal (≤7.8 pg/ml) | 16/21 (76.1) | 0.87 (0.74–1.09) |
| Abnormal | 23/51 (45.0) | 1.09 (0.19–1.20) |
| IL-6/IL-10 | 0.002 | |
| ≤0.09 | 15/38 (39.4) | 0.65 (0.29–1.19) |
| >0.10 | 24/34 (70.5) | 3.87 (2.81–4.98) |
Multivariate analysis results of factors affecting recurrence risk in all enrolled patients. Data in parentheses are percentages. HR, hazard ratio, 95% CI, 95% confidence interval. IL-6, interleukin-6; IL-10, interleukin-10.