Table 3. Associations of diabetes susceptibility variants with risk of incident CVD.
| Pooled analysis | ||||||
| Gene | SNPa | Risk alleleb/other | Model 1c HR (95% CI) | P | Model 2d HR (95% CI) | P |
| Variants with an effect on β-cell function | ||||||
| ADRA2A | rs10885122 | G/T | 1.021 (0.926 ; 1.126) | 0.6795 | 1.017 (0.922 ; 1.122) | 0.7320 |
| CENTD2 | rs1552224 | T/G | 0.971 (0.898 ; 1.051) | 0.4680 | 0.973 (0.899 ; 1.052) | 0.4887 |
| DGKB | rs2191349 | G/T | 1.026 (0.967 ; 1.090) | 0.3936 | 1.026 (0.966 ; 1.089) | 0.4069 |
| KCNQ1 | rs231362 | T/C | 0.993 (0.936 ; 1.055) | 0.8307 | 1.002 (0.944 ; 1.064) | 0.9485 |
| PROX1 | rs340874 | C/T | 1.018 (0.958 ; 1.081) | 0.5714 | 1.007 (0.948 ; 1.070) | 0.8114 |
| G6PC2 | rs560887 | G/A | 1.025 (0.961 ; 1.095) | 0.4524 | 1.023 (0.959 ; 1.092) | 0.4772 |
| GLIS3 | rs7034200 | C/A | 0.982 (0.924 ; 1.044) | 0.5672 | 0.983 (0.925 ; 1.045) | 0.5895 |
| MADD | rs7944584 | A/T | 1.000 (0.932 ; 1.073) | 0.9968 | 0.997 (0.930 ; 1.070) | 0.9396 |
| CDKN2A | rs10811661 | T/C | 1.027 (0.946 ; 1.115) | 0.5193 | 1.021 (0.941 ; 1.109) | 0.2577 |
| MTNR1B | rs10830963 | G/C | 0.997 (0.932 ; 1.066) | 0.9301 | 0.992 (0.927 ; 1.061) | 0.8087 |
| HHEX | rs1111875 | G/A or C/T | 0.968 (0.912 ; 1.028) | 0.2945 | 0.967 (0.911 ; 1.027) | 0.2768 |
| CDC123 | rs12779790 | G/A | 0.978 (0.906 ; 1.056) | 0.5677 | 0.982 (0.909 ; 1.061) | 0.6455 |
| SLC30A8 | rs13266634 | C/T | 0.994 (0.933 ; 1.059) | 0.8539 | 1.004 (0.942 ; 1.069) | 0.9124 |
| IGF2BP2 | rs4402960 | T/G | 1.013 (0.949 ; 1.081) | 0.7027 | 1.009 (0.945 ; 1.078) | 0.7864 |
| THADA | rs7578597 | T/C | 0.971 (0.880 ; 1.071) | 0.5573 | 0.972 (0.881 ; 1.073 | 0.5761 |
| TCF7L2 | rs7903146 | T/C | 1.050 (0.983 ; 1.122) | 0.1454 | 1.046 (0.979 ; 1.117) | 0.1871 |
| TSPAN8 | rs7961581 | C/T | 1.025 (0.957 ; 1.098) | 0.4831 | 1.016 (0.948 ; 1.088) | 0.6525 |
| JAZF1 | rs864745 | A/G or T/C | 1.034 (0.973 ; 1.098) | 0.2827 | 1.039 (0.978 ; 1.104) | 0.2130 |
| CDKAL1 | rs7756992 | G/A | 1.051 (0.985 ; 1.123) | 0.1329 | 1.046 (0.980 ; 1.117) | 0.1754 |
| GIPR | rs10423928 | A/T | 1.003 (0.935 ; 1.077) | 0.9261 | 0.996 (0.928 ; 1.069) | 0.9151 |
| C2CD4B | rs11071657 | A/G | 1.067 (1.003 ; 1.315) | 0.0384 | 1.067 (1.003 ; 1.135) | 0.0385 |
| GCK | rs4607517 | A/G | 0.998 (0.918 ; 1.085) | 0.9666 | 0.982 (0.903 ; 1.068) | 0.6670 |
| HNF1A | rs7957197 | T/A | 1.015 (0.943 ; 1.093) | 0.6891 | 1.011 (0.938 ; 1.088) | 0.7801 |
| HNF1B | rs7501939 | T/C | 0.980 (0.922 ; 1.042) | 0.5234 | 0.982 (0.924 ; 1.044) | 0.5619 |
| C2CD4A | rs7172432 | A/G | 1.039 (0.977 ; 1.104) | 0.2208 | 1.041 (0.980 ; 1.106) | 0.1936 |
| Variants with an effect on insulin sensitivity | ||||||
| GCKR | rs780094 | G/A | 1.073 (1.008 ; 1.143) | 0.0277 | 1.076 (1.010 ; 1.146) | 0.0229 |
| PPARG | rs1801282 | C/G | 1.028 (0.941 ; 1.122) | 0.5457 | 1.023 (0.937 ; 1.118) | 0.6070 |
| ADAMTS9 | rs4607103 | C/T | 0.983 (0.915 ; 1.057) | 0.6416 | 0.981 (0.913 ; 1.055) | 0.6088 |
| IGF1 | rs35767 | C/T | 1.067 (0.979 ; 1.163) | 0.1421 | 1.059 (0.972 ; 1.155) | 0.1925 |
| Variant with an effect on adiposity | ||||||
| FTO | rs8050136 | A/C | 0.973 (0.915 ; 1.034) | 0.3746 | 0.974 (0.916 ; 1.036) | 0.4100 |
| Variants with unknown physiology | ||||||
| FADS1 | rs174550 | A/G | 0.999 (0.937 ; 1.066) | 0.9809 | 0.996 (0.934 ; 1.062) | 0.9038 |
| CRY2 | rs11605924 | A/C | 1.015 (0.954 ; 1.078) | 0.6432 | 1.015 (0.955 ; 1.079) | 0.6357 |
| ZFAND6 | rs11634397 | G/A | 1.025 (0.961 ; 1.094) | 0.4512 | 1.033 (0.968 ; 1.103) | 0.3254 |
| ADCY5 | rs11708067 | A/G | 1.012 (0.944 ; 1.084) | 0.7356 | 1.005 (0.938 ; 1.077) | 0.8878 |
| SLC2A2 | rs11920090 | A/T | 1.153 (1.061 ; 1.254) | 0.0009 | 1.164 (1.070 ; 1.267) | 0.0004 |
| CHCHD9 | rs13292136 | C/T | 0.997 (0.892 ; 1.114) | 0.9533 | 0.998 (0.893 ; 1.116) | 0.9731 |
| HMGA2 | rs1531343 | C/G | 1.004 (0.902 ; 1.117) | 0.9455 | 0.978 (0.879 ; 1.090) | 0.6913 |
| BCL11A | rs243021 | T/C | 1.011 (0.952 ; 1.073) | 0.7198 | 1.010 (0.951 ; 1.073) | 0.7432 |
| ZBED3 | rs4457053 | G/A | 0.975 (0.912 ; 1.042) | 0.4596 | 0.969 (0.907 ; 1.037) | 0.3639 |
| DUSP9 | rs5945326 | A/G | 0.989 (0.935 ; 1.047) | 0.7146 | 0.988 (0.933 ; 1.045) | 0.6683 |
| PRC1 | rs8042680 | A/C | 1.029 (0.964 ; 1.099) | 0.3831 | 1.024 (0.959 ; 1.093) | 0.4790 |
| TP53INP1 | rs896854 | A/G | 1.027 (0.967 ; 1.092) | 0.3865 | 1.033 (0.972 ; 1.098) | 0.2908 |
| KLF14 | rs972283 | G/A | 1.052 (0.991 ; 1.118) | 0.0998 | 1.051 (0.989 ; 1.117) | 0.1076 |
| NOTCH2 | rs10923931 | T/G | 1.096 (0.994 ; 1.209) | 0.0667 | 1.104 (1.001 ; 1.217) | 0.0481 |
| KCNQ1 | rs2237895 | C/A | 1.025 (0.964 ; 1.089) | 0.4336 | 1.020 (0.959 ; 1.084) | 0.5358 |
| VPS13C | rs17271305 | G/A | 0.988 (0.930 ; 1.050) | 0.6928 | 0.992 (0.933 ; 1.054) | 0.7960 |
| Gene score | 1.020 (1.007 ; 1.033) | 0.0018 | 1.018 (1.006 ; 1.031) | 0.0043 | ||
a
SNP, single nucleotide polymorphism
b
According to type 2 diabetes risk increasing allele in original reports
c
Model 1 adjusted for sex, age and cohort. HR is per risk increasing allele
d
Model 2 adjusted for sex, age, cohort and prevalent diabetes. HR is per risk increasing allele