Figure 2. Main histological findings.

This panel of graphs provides the main histological results arising from the quantitative analysis of the muscle biopsies. The mean ± SD of the obtained values are represented by histograms and error-bars, and because of the low number of biopsies analyzed, individual values are superimposed to the histograms. The results obtained in GRMD^ctrl dogs are in red on the left of the graphs, and the results obtained in GRMD^CsA+P are in green, on the right of the graphs. As biopsies were sampled at two points during the treatment, the values obtained at 6 months are represented in the left-hand graphs and the values at 9 months by the right-hand graphs. The pathological index was not significantly modified in the treated dogs, either at 6 months (A), or at 9 months (B). The amount of calcified myofibers was increased in treated dogs biopsies, at 6 (C) and 9 (D) months. The mean myofiber diameter was lower in treated dogs at 6 (E) and 9 (F) months. Finally, the biopsies originating from treated dogs contained significantly less slow-type fibers at 6 (G) and 9 (H) months. * means that p<0.05 ; ** means that p<0.01.